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000180369 1001_ $$0P:(DE-He78)51635089578f68fc9efdb61e6a760b64$$aWalle, Thomas$$b0$$eFirst author
000180369 245__ $$aCytokine release syndrome-like serum responses after COVID-19 vaccination are frequent and clinically inapparent under cancer immunotherapy.
000180369 260__ $$aLondon$$bNature Research$$c2022
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000180369 500__ $$a#EA:F230#F230# / 2022 Sep;3(9):1039-1051 / HI-TRON
000180369 520__ $$aPatients with cancer frequently receive immune-checkpoint inhibitors (ICIs), which may modulate immune responses to COVID-19 vaccines. Recently, cytokine release syndrome (CRS) was observed in a patient with cancer who received BTN162b2 vaccination under ICI treatment. Here, we analyzed adverse events and serum cytokines in patients with 23 different tumors undergoing (n = 64) or not undergoing (n = 26) COVID-19 vaccination under ICI therapy in a prospectively planned German single-center cohort study (n = 220). We did not observe clinically relevant CRS (≥grade 2) after vaccination (95% CI 0-5.6%; Common Terminology of Adverse Events v.5.0) in this small cohort. Within 4 weeks after vaccination, serious adverse events occurred in eight patients (12.5% 95% CI 5.6-23%), six patients were hospitalized and two patients died. Despite absence of CRS symptoms, a set of pairwise-correlated CRS-associated cytokines, including CXCL8 and interleukin-6 was >1.5-fold upregulated in 40% (95% CI 23.9-57.9%) of patients after vaccination. Hence, elevated cytokine levels are common and not sufficient to establish CRS diagnosis.
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000180369 7001_ $$0P:(DE-HGF)0$$aBajaj, Sunanjay$$b1$$eFirst author
000180369 7001_ $$0P:(DE-He78)7fb0841f5e88928308e29474e3170818$$aKraske, Joscha A$$b2
000180369 7001_ $$aRösner, Thomas$$b3
000180369 7001_ $$aCussigh, Christiane S$$b4
000180369 7001_ $$aKälber, Katharina A$$b5
000180369 7001_ $$aMüller, Lisa Jasmin$$b6
000180369 7001_ $$aStrobel, Sophia Boyoung$$b7
000180369 7001_ $$aBurghaus, Jana$$b8
000180369 7001_ $$aKallenberger, Stefan M$$b9
000180369 7001_ $$0P:(DE-He78)c65b1d3644b08872d944d3cd069737ce$$aStein-Thöringer, Christoph$$b10
000180369 7001_ $$aJenzer, Maximilian$$b11
000180369 7001_ $$0P:(DE-He78)83ba3db324720df82864fa5c863fec08$$aSchubert, Antonia$$b12
000180369 7001_ $$aKahle, Steffen$$b13
000180369 7001_ $$aWilliams, Anja$$b14
000180369 7001_ $$0P:(DE-He78)25e88e7894cbce24806666301288f7e5$$aHoyler, Birgit$$b15
000180369 7001_ $$aZielske, Lin$$b16
000180369 7001_ $$aSkatula, Renate$$b17
000180369 7001_ $$0P:(DE-He78)7f98cc11197c11a7645e4c8e1dba83a4$$aSawall, Stefanie$$b18
000180369 7001_ $$0P:(DE-He78)1401445b374879f90e840ca2e6a96bac$$aLeber, Mathias Felix$$b19
000180369 7001_ $$aKunes, Russell Z$$b20
000180369 7001_ $$aKrisam, Johannes$$b21
000180369 7001_ $$aFremd, Carlo$$b22
000180369 7001_ $$aSchneeweiss, Andreas$$b23
000180369 7001_ $$aKrauss, Jürgen$$b24
000180369 7001_ $$aApostolidis, Leonidas$$b25
000180369 7001_ $$aBerger, Anne Katrin$$b26
000180369 7001_ $$0P:(DE-He78)f54d0426f2215c539d3a7ae1b400b57d$$aHaag, Georg Martin$$b27
000180369 7001_ $$aZschäbitz, Stefanie$$b28
000180369 7001_ $$0P:(DE-He78)0a4053be7ffd6aa9bef69de28753a601$$aHalama, Niels$$b29
000180369 7001_ $$aSpringfeld, Christoph$$b30
000180369 7001_ $$aKirsten, Romy$$b31
000180369 7001_ $$0P:(DE-He78)00858755eb8a7861491b50e2d00e52f1$$aHassel, Jessica$$b32
000180369 7001_ $$0P:(DE-He78)ed0321409c9cde20b380ae663dbcefd1$$aJäger, Dirk$$b33
000180369 7001_ $$aInvestigators, NCT ANTICIPATE$$b34$$eCollaboration Author
000180369 7001_ $$0P:(DE-He78)833f90e2abdd29594ad5c4f08600f191$$aUngerechts, Guy$$b35$$eLast author
000180369 7001_ $$aCussigh, Christiane S$$b36
000180369 7001_ $$aKälber, Katharina A$$b37
000180369 7001_ $$aAbdelrahim, Omar$$b38
000180369 7001_ $$aBusch, Elena$$b39
000180369 7001_ $$aDerigs, Patrick$$b40
000180369 7001_ $$aDischinger, Katharina$$b41
000180369 7001_ $$aMitri, Fouad$$b42
000180369 7001_ $$aSchmidt, Kerstin$$b43
000180369 7001_ $$aBhatti, Irfan A$$b44
000180369 7001_ $$aGrün, Barbara$$b45
000180369 7001_ $$aHohmann, Nicolas$$b46
000180369 7001_ $$aWoydack, Lena$$b47
000180369 7001_ $$aZhang, Xin-Wen$$b48
000180369 7001_ $$aFerber, Dyke$$b49
000180369 7001_ $$aMock, Andreas$$b50
000180369 7001_ $$aPompecki, Tillmann$$b51
000180369 7001_ $$aSchank, Timo$$b52
000180369 7001_ $$aFremd, Carlo$$b53
000180369 7001_ $$aHaag, Georg M$$b54
000180369 7001_ $$aHalama, Niels$$b55
000180369 7001_ $$aKirsten, Romy$$b56
000180369 7001_ $$aHassel, Jessica C$$b57
000180369 7001_ $$0P:(DE-He78)ed0321409c9cde20b380ae663dbcefd1$$aJäger, Dirk$$b58
000180369 7001_ $$0P:(DE-He78)833f90e2abdd29594ad5c4f08600f191$$aUngerechts, Guy$$b59$$eLast author
000180369 773__ $$0PERI:(DE-600)3005299-3$$a10.1038/s43018-022-00398-7$$n9$$p1039-1051$$tNature cancer$$v3$$x2662-1347$$y2022
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