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| Home > Publications database > Cytokine release syndrome-like serum responses after COVID-19 vaccination are frequent and clinically inapparent under cancer immunotherapy. > print |
| 001 | 180369 | ||
| 005 | 20240229145616.0 | ||
| 024 | 7 | _ | |a 10.1038/s43018-022-00398-7 |2 doi |
| 024 | 7 | _ | |a pmid:35715501 |2 pmid |
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| 037 | _ | _ | |a DKFZ-2022-01283 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Walle, Thomas |0 P:(DE-He78)51635089578f68fc9efdb61e6a760b64 |b 0 |e First author |
| 245 | _ | _ | |a Cytokine release syndrome-like serum responses after COVID-19 vaccination are frequent and clinically inapparent under cancer immunotherapy. |
| 260 | _ | _ | |a London |c 2022 |b Nature Research |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1698997740_23210 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #EA:F230#F230# / 2022 Sep;3(9):1039-1051 / HI-TRON |
| 520 | _ | _ | |a Patients with cancer frequently receive immune-checkpoint inhibitors (ICIs), which may modulate immune responses to COVID-19 vaccines. Recently, cytokine release syndrome (CRS) was observed in a patient with cancer who received BTN162b2 vaccination under ICI treatment. Here, we analyzed adverse events and serum cytokines in patients with 23 different tumors undergoing (n = 64) or not undergoing (n = 26) COVID-19 vaccination under ICI therapy in a prospectively planned German single-center cohort study (n = 220). We did not observe clinically relevant CRS (≥grade 2) after vaccination (95% CI 0-5.6%; Common Terminology of Adverse Events v.5.0) in this small cohort. Within 4 weeks after vaccination, serious adverse events occurred in eight patients (12.5% 95% CI 5.6-23%), six patients were hospitalized and two patients died. Despite absence of CRS symptoms, a set of pairwise-correlated CRS-associated cytokines, including CXCL8 and interleukin-6 was >1.5-fold upregulated in 40% (95% CI 23.9-57.9%) of patients after vaccination. Hence, elevated cytokine levels are common and not sufficient to establish CRS diagnosis. |
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| 700 | 1 | _ | |a Bajaj, Sunanjay |0 P:(DE-HGF)0 |b 1 |e First author |
| 700 | 1 | _ | |a Kraske, Joscha A |0 P:(DE-He78)7fb0841f5e88928308e29474e3170818 |b 2 |
| 700 | 1 | _ | |a Rösner, Thomas |b 3 |
| 700 | 1 | _ | |a Cussigh, Christiane S |b 4 |
| 700 | 1 | _ | |a Kälber, Katharina A |b 5 |
| 700 | 1 | _ | |a Müller, Lisa Jasmin |b 6 |
| 700 | 1 | _ | |a Strobel, Sophia Boyoung |b 7 |
| 700 | 1 | _ | |a Burghaus, Jana |b 8 |
| 700 | 1 | _ | |a Kallenberger, Stefan M |b 9 |
| 700 | 1 | _ | |a Stein-Thöringer, Christoph |0 P:(DE-He78)c65b1d3644b08872d944d3cd069737ce |b 10 |
| 700 | 1 | _ | |a Jenzer, Maximilian |b 11 |
| 700 | 1 | _ | |a Schubert, Antonia |0 P:(DE-He78)83ba3db324720df82864fa5c863fec08 |b 12 |
| 700 | 1 | _ | |a Kahle, Steffen |b 13 |
| 700 | 1 | _ | |a Williams, Anja |b 14 |
| 700 | 1 | _ | |a Hoyler, Birgit |0 P:(DE-He78)25e88e7894cbce24806666301288f7e5 |b 15 |
| 700 | 1 | _ | |a Zielske, Lin |b 16 |
| 700 | 1 | _ | |a Skatula, Renate |b 17 |
| 700 | 1 | _ | |a Sawall, Stefanie |0 P:(DE-He78)7f98cc11197c11a7645e4c8e1dba83a4 |b 18 |
| 700 | 1 | _ | |a Leber, Mathias Felix |0 P:(DE-He78)1401445b374879f90e840ca2e6a96bac |b 19 |
| 700 | 1 | _ | |a Kunes, Russell Z |b 20 |
| 700 | 1 | _ | |a Krisam, Johannes |b 21 |
| 700 | 1 | _ | |a Fremd, Carlo |b 22 |
| 700 | 1 | _ | |a Schneeweiss, Andreas |b 23 |
| 700 | 1 | _ | |a Krauss, Jürgen |b 24 |
| 700 | 1 | _ | |a Apostolidis, Leonidas |b 25 |
| 700 | 1 | _ | |a Berger, Anne Katrin |b 26 |
| 700 | 1 | _ | |a Haag, Georg Martin |0 P:(DE-He78)f54d0426f2215c539d3a7ae1b400b57d |b 27 |
| 700 | 1 | _ | |a Zschäbitz, Stefanie |b 28 |
| 700 | 1 | _ | |a Halama, Niels |0 P:(DE-He78)0a4053be7ffd6aa9bef69de28753a601 |b 29 |
| 700 | 1 | _ | |a Springfeld, Christoph |b 30 |
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| 700 | 1 | _ | |a Hassel, Jessica |0 P:(DE-He78)00858755eb8a7861491b50e2d00e52f1 |b 32 |
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| 700 | 1 | _ | |a Investigators, NCT ANTICIPATE |b 34 |e Collaboration Author |
| 700 | 1 | _ | |a Ungerechts, Guy |0 P:(DE-He78)833f90e2abdd29594ad5c4f08600f191 |b 35 |e Last author |
| 700 | 1 | _ | |a Cussigh, Christiane S |b 36 |
| 700 | 1 | _ | |a Kälber, Katharina A |b 37 |
| 700 | 1 | _ | |a Abdelrahim, Omar |b 38 |
| 700 | 1 | _ | |a Busch, Elena |b 39 |
| 700 | 1 | _ | |a Derigs, Patrick |b 40 |
| 700 | 1 | _ | |a Dischinger, Katharina |b 41 |
| 700 | 1 | _ | |a Mitri, Fouad |b 42 |
| 700 | 1 | _ | |a Schmidt, Kerstin |b 43 |
| 700 | 1 | _ | |a Bhatti, Irfan A |b 44 |
| 700 | 1 | _ | |a Grün, Barbara |b 45 |
| 700 | 1 | _ | |a Hohmann, Nicolas |b 46 |
| 700 | 1 | _ | |a Woydack, Lena |b 47 |
| 700 | 1 | _ | |a Zhang, Xin-Wen |b 48 |
| 700 | 1 | _ | |a Ferber, Dyke |b 49 |
| 700 | 1 | _ | |a Mock, Andreas |b 50 |
| 700 | 1 | _ | |a Pompecki, Tillmann |b 51 |
| 700 | 1 | _ | |a Schank, Timo |b 52 |
| 700 | 1 | _ | |a Fremd, Carlo |b 53 |
| 700 | 1 | _ | |a Haag, Georg M |b 54 |
| 700 | 1 | _ | |a Halama, Niels |b 55 |
| 700 | 1 | _ | |a Kirsten, Romy |b 56 |
| 700 | 1 | _ | |a Hassel, Jessica C |b 57 |
| 700 | 1 | _ | |a Jäger, Dirk |0 P:(DE-He78)ed0321409c9cde20b380ae663dbcefd1 |b 58 |
| 700 | 1 | _ | |a Ungerechts, Guy |0 P:(DE-He78)833f90e2abdd29594ad5c4f08600f191 |b 59 |e Last author |
| 773 | _ | _ | |a 10.1038/s43018-022-00398-7 |0 PERI:(DE-600)3005299-3 |n 9 |p 1039-1051 |t Nature cancer |v 3 |y 2022 |x 2662-1347 |
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