TY  - JOUR
AU  - Eichkorn, T
AU  - Karger, Christian
AU  - Brons, S
AU  - Koerber, Stefan A
AU  - Mielke, Thomas
AU  - Haberer, Thomas
AU  - Debus, Jürgen
AU  - Herfarth, Klaus
TI  - Results of a prospective randomized trial on long-term effectiveness of protons and carbon ions in prostate cancer: LEM I and α/β=2Gy overestimates the RBE.
JO  - Radiotherapy and oncology
VL  - 173
SN  - 0167-8140
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2022-01289
SP  - 223-230
PY  - 2022
N1  - 2022 Jun 14;173:223-230
AB  - To analyze the long-term effectiveness of carbon ions relative to protons in the prospective randomized controlled ion prostate irradiation (IPI) trial.Effectiveness via PSA assessment in a randomized study on prostate irradiation with 20x3.3Gy(RBE) protons versus carbon ions was analyzed in 92 patients. Proton RBE was based on a fixed RBE of 1.1 while the local effect model (LEM) I and an α/β=2Gy was used for carbon ions. The dose in the prostate was recalculated based on the delivered treatment plan using LEM I and LEM IV and different α/β values.Five-year overall and progression free survival was 98
KW  - Carbon ion and proton radiotherapy (Other)
KW  - Local effect model (LEM) (Other)
KW  - Prostate cancer (Other)
KW  - Relative biological effectiveness (RBE) (Other)
KW  - α/β ratio (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35714806
DO  - DOI:10.1016/j.radonc.2022.06.006
UR  - https://inrepo02.dkfz.de/record/180375
ER  -