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@ARTICLE{Jung:180385,
      author       = {A. Y. Jung$^*$ and T. U. Ahearn and S. Behrens$^*$ and P.
                      Middha$^*$ and M. K. Bolla and Q. Wang and V. Arndt$^*$ and
                      K. J. Aronson and A. Augustinsson and L. E. Beane Freeman
                      and H. Becher and H. Brenner$^*$ and F. Canzian$^*$ and L.
                      A. Carey and K. Czene and A. H. Eliassen and M. Eriksson and
                      D. G. Evans and J. D. Figueroa and L. Fritschi and M.
                      Gabrielson and G. G. Giles and P. Guénel and A. Hadjisavvas
                      and C. A. Haiman and N. Håkansson and P. Hall and U.
                      Hamann$^*$ and R. Hoppe and J. L. Hopper and A. Howell and
                      D. J. Hunter and A. Hüsing$^*$ and R. Kaaks$^*$ and V.-M.
                      Kosma and S. Koutros and P. Kraft and J. V. Lacey and L. Le
                      Marchand and J. Lissowska and M. A. Loizidou and A.
                      Mannermaa and T. Maurer and R. A. Murphy and A. F. Olshan
                      and H. Olsson and A. V. Patel and C. M. Perou and G. Rennert
                      and R. Shibli and X.-O. Shu and M. C. Southey and J. Stone
                      and R. M. Tamimi and L. R. Teras and M. A. Troester and T.
                      Truong and C. M. Vachon and S. S. Wang and A. Wolk and A. H.
                      Wu and X. R. Yang and W. Zheng and A. M. Dunning and P. D.
                      P. Pharoah and D. F. Easton and R. L. Milne and N.
                      Chatterjee and M. K. Schmidt and M. García-Closas and J.
                      Chang-Claude$^*$},
      collaboration = {C. Consortium},
      title        = {{D}istinct reproductive risk profiles for intrinsic-like
                      breast cancer subtypes: pooled analysis of population-based
                      studies.},
      journal      = {Journal of the National Cancer Institute},
      volume       = {114},
      number       = {12},
      issn         = {0027-8874},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2022-01299},
      pages        = {1706-1719},
      year         = {2022},
      note         = {#EA:C020#LA:C020# / 2022 Dec 8;114(12):1706-1719},
      abstract     = {Reproductive factors have been shown to be differentially
                      associated with risk of estrogen receptor (ER) positive and
                      ER-negative breast cancer. However, their associations with
                      intrinsic-like subtypes are less clear.Analyses included up
                      to 23,353 cases, and 71,072 controls pooled from 31
                      population-based case-control or cohort studies in the
                      Breast Cancer Association Consortium across 16 countries on
                      4 continents. Polytomous logistic regression was used to
                      estimate the association between reproductive factors and
                      risk of breast cancer by intrinsic-like subtypes (luminal
                      A-like, luminal B-like, luminal B-HER2-like,
                      HER2-enriched-like, and triple-negative) and by
                      invasiveness. All statistical tests were 2-sided.Compared to
                      nulliparous women, parous women had a lower risk of luminal
                      A-like, luminal B-like, luminal B-HER2-like and
                      HER2-enriched-like disease. This association was apparent
                      only after approximately 10 years since last birth and
                      became stronger with increasing time (odds ratio [OR] =
                      0.59, $95\%$ confidence interval [CI] = 0.49 to 0.71; and OR
                      = 0.36, $95\%$ CI = 0.28 to 0.46; for multiparous women with
                      luminal A-like tumors 20-<25 years after last birth and
                      45-<50 years after last birth, respectively). In contrast,
                      parous women had a higher risk of triple-negative breast
                      cancer right after their last birth (for multiparous women:
                      OR = 3.12, $95\%CI$ = 2.02 to 4.83) that was attenuated with
                      time but persisted for decades (OR = 1.03, $95\%CI$ = 0.79
                      to 1.34, for multiparous women 25 to < 30 years after last
                      birth). Older age at first birth (P-heterogeneity<.001 for
                      triple-negative compared to luminal-A like) and
                      breastfeeding (P-heterogeneity<.001 for triple-negative
                      compared to luminal-A like) were associated with lower risk
                      of triple-negative but not with other disease subtypes.
                      Younger age at menarche was associated with higher risk of
                      all subtypes; older age at menopause was associated with
                      higher risk of luminal A-like but not triple-negative breast
                      cancer. Associations for in situ tumors were similar to
                      luminal A-like.This large and comprehensive study
                      demonstrates a distinct reproductive risk factor profile for
                      triple-negative breast cancer compared to other subtypes,
                      with implications for the understanding of disease etiology
                      and risk prediction.},
      keywords     = {breast cancer (Other) / intrinsic-like subtypes (Other) /
                      reproductive risk factors (Other) / triple-negative (Other)},
      cin          = {C020 / C070 / C120 / HD01 / C055 / B072 / B070},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)C055-20160331 / I:(DE-He78)B072-20160331 /
                      I:(DE-He78)B070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35723569},
      doi          = {10.1093/jnci/djac117},
      url          = {https://inrepo02.dkfz.de/record/180385},
}