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024 7 _ |a 10.1093/jnci/djac117
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024 7 _ |a 0027-8874
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024 7 _ |a 0198-0157
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024 7 _ |a 1460-2105
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037 _ _ |a DKFZ-2022-01299
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Jung, Audrey Ying-Chee
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245 _ _ |a Distinct reproductive risk profiles for intrinsic-like breast cancer subtypes: pooled analysis of population-based studies.
260 _ _ |a Oxford
|c 2022
|b Oxford Univ. Press
336 7 _ |a article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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500 _ _ |a #EA:C020#LA:C020# / 2022 Dec 8;114(12):1706-1719
520 _ _ |a Reproductive factors have been shown to be differentially associated with risk of estrogen receptor (ER) positive and ER-negative breast cancer. However, their associations with intrinsic-like subtypes are less clear.Analyses included up to 23,353 cases, and 71,072 controls pooled from 31 population-based case-control or cohort studies in the Breast Cancer Association Consortium across 16 countries on 4 continents. Polytomous logistic regression was used to estimate the association between reproductive factors and risk of breast cancer by intrinsic-like subtypes (luminal A-like, luminal B-like, luminal B-HER2-like, HER2-enriched-like, and triple-negative) and by invasiveness. All statistical tests were 2-sided.Compared to nulliparous women, parous women had a lower risk of luminal A-like, luminal B-like, luminal B-HER2-like and HER2-enriched-like disease. This association was apparent only after approximately 10 years since last birth and became stronger with increasing time (odds ratio [OR] = 0.59, 95% confidence interval [CI] = 0.49 to 0.71; and OR = 0.36, 95% CI = 0.28 to 0.46; for multiparous women with luminal A-like tumors 20-<25 years after last birth and 45-<50 years after last birth, respectively). In contrast, parous women had a higher risk of triple-negative breast cancer right after their last birth (for multiparous women: OR = 3.12, 95%CI = 2.02 to 4.83) that was attenuated with time but persisted for decades (OR = 1.03, 95%CI = 0.79 to 1.34, for multiparous women 25 to < 30 years after last birth). Older age at first birth (P-heterogeneity<.001 for triple-negative compared to luminal-A like) and breastfeeding (P-heterogeneity<.001 for triple-negative compared to luminal-A like) were associated with lower risk of triple-negative but not with other disease subtypes. Younger age at menarche was associated with higher risk of all subtypes; older age at menopause was associated with higher risk of luminal A-like but not triple-negative breast cancer. Associations for in situ tumors were similar to luminal A-like.This large and comprehensive study demonstrates a distinct reproductive risk factor profile for triple-negative breast cancer compared to other subtypes, with implications for the understanding of disease etiology and risk prediction.
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650 _ 7 |a breast cancer
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650 _ 7 |a intrinsic-like subtypes
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650 _ 7 |a reproductive risk factors
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650 _ 7 |a triple-negative
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700 1 _ |a Ahearn, Thomas U
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700 1 _ |a Behrens, Sabine
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700 1 _ |a Middha, Pooja
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700 1 _ |a Wang, Qin
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700 1 _ |a Arndt, Volker
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700 1 _ |a Aronson, Kristan J
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700 1 _ |a Augustinsson, Annelie
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700 1 _ |a Beane Freeman, Laura E
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700 1 _ |a Becher, Heiko
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700 1 _ |a Brenner, Hermann
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700 1 _ |a Canzian, Federico
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700 1 _ |a Carey, Lisa A
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700 1 _ |a Eliassen, A Heather
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700 1 _ |a Evans, D Gareth
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700 1 _ |a Figueroa, Jonine D
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700 1 _ |a Fritschi, Lin
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700 1 _ |a Gabrielson, Marike
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700 1 _ |a Giles, Graham G
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700 1 _ |a Guénel, Pascal
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700 1 _ |a Hadjisavvas, Andreas
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700 1 _ |a Haiman, Christopher A
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700 1 _ |a Håkansson, Niclas
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700 1 _ |a Hall, Per
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700 1 _ |a Hamann, Ute
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700 1 _ |a Hoppe, Reiner
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700 1 _ |a Hopper, John L
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700 1 _ |a Howell, Anthony
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700 1 _ |a Hunter, David J
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700 1 _ |a Kaaks, Rudolf
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700 1 _ |a Kosma, Veli-Matti
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700 1 _ |a Koutros, Stella
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700 1 _ |a Kraft, Peter
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700 1 _ |a Lacey, James V
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700 1 _ |a Le Marchand, Loic
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700 1 _ |a Lissowska, Jolanta
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700 1 _ |a Loizidou, Maria A
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700 1 _ |a Mannermaa, Arto
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700 1 _ |a Maurer, Tabea
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700 1 _ |a Olshan, Andrew F
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700 1 _ |a Patel, Alpa V
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700 1 _ |a Vachon, Celine M
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700 1 _ |a Wang, Sophia S
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700 1 _ |a Wolk, Alicja
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700 1 _ |a Wu, Anna H
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700 1 _ |a Yang, Xiaohong R
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700 1 _ |a Zheng, Wei
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700 1 _ |a Dunning, Alison M
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700 1 _ |a Pharoah, Paul D P
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700 1 _ |a Easton, Douglas F
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700 1 _ |a Milne, Roger L
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700 1 _ |a Chatterjee, Nilanjan
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700 1 _ |a Schmidt, Marjanka K
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