TY  - JOUR
AU  - Watts, Eleanor L
AU  - Perez-Cornago, Aurora
AU  - Fensom, Georgina K
AU  - Smith-Byrne, Karl
AU  - Noor, Urwah
AU  - Andrews, Colm D
AU  - Gunter, Marc J
AU  - Holmes, Michael V
AU  - Martin, Richard M
AU  - Tsilidis, Konstantinos K
AU  - Albanes, Demetrius
AU  - Barricarte, Aurelio
AU  - Bueno-de-Mesquita, H Bas
AU  - Cohn, Barbara A
AU  - Deschasaux-Tanguy, Melanie
AU  - Dimou, Niki L
AU  - Ferrucci, Luigi
AU  - Flicker, Leon
AU  - Freedman, Neal D
AU  - Giles, Graham G
AU  - Giovannucci, Edward L
AU  - Haiman, Christopher A
AU  - Hankey, Graham J
AU  - Holly, Jeffrey M P
AU  - Huang, Jiaqi
AU  - Huang, Wen-Yi
AU  - Hurwitz, Lauren M
AU  - Kaaks, Rudolf
AU  - Kubo, Tatsuhiko
AU  - Le Marchand, Loic
AU  - MacInnis, Robert J
AU  - Männistö, Satu
AU  - Metter, E Jeffrey
AU  - Mikami, Kazuya
AU  - Mucci, Lorelei A
AU  - Olsen, Anja W
AU  - Ozasa, Kotaro
AU  - Palli, Domenico
AU  - Penney, Kathryn L
AU  - Platz, Elizabeth A
AU  - Pollak, Michael N
AU  - Roobol, Monique J
AU  - Schaefer, Catherine A
AU  - Schenk, Jeannette M
AU  - Stattin, Pär
AU  - Tamakoshi, Akiko
AU  - Thysell, Elin
AU  - Tsai, Chiaojung Jillian
AU  - Touvier, Mathilde
AU  - Van Den Eeden, Stephen K
AU  - Weiderpass, Elisabete
AU  - Weinstein, Stephanie J
AU  - Wilkens, Lynne R
AU  - Yeap, Bu B
AU  - Allen, Naomi E
AU  - Key, Timothy J
AU  - Travis, Ruth C
AU  - Eeles, Rosalind A
AU  - Haiman, Christopher A
AU  - Kote-Jarai, Zsofia
AU  - Schumacher, Fredrick R
AU  - Benlloch, Sara
AU  - Olama, Ali Amin Al
AU  - Muir, Kenneth R
AU  - Berndt, Sonja I
AU  - Conti, David V
AU  - Wiklund, Fredrik
AU  - Chanock, Stephen
AU  - Wang, Ying
AU  - Tangen, Catherine M
AU  - Batra, Jyotsna
AU  - Clements, Judith A
TI  - Circulating insulin-like growth factors and risks of overall, aggressive and early-onset prostate cancer: a collaborative analysis of 20 prospective studies and Mendelian randomization analysis.
JO  - International journal of epidemiology
VL  - 52
IS  - 1
SN  - 0300-5771
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2022-01319
SP  - 71-86
PY  - 2023
N1  - 2023 Feb 8;52(1):71-86
AB  - Previous studies had limited power to assess the associations of circulating insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) with clinically relevant prostate cancer as a primary endpoint, and the association of genetically predicted IGF-I with aggressive prostate cancer is not known. We aimed to investigate the associations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 concentrations with overall, aggressive and early-onset prostate cancer.Prospective analysis of biomarkers using the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset (up to 20 studies, 17 009 prostate cancer cases, including 2332 aggressive cases). Odds ratios (OR) and 95
KW  - Insulin-like growth factor-I (Other)
KW  - Mendelian randomization (Other)
KW  - aggressive prostate cancer (Other)
KW  - international consortia (Other)
KW  - prospective analysis (Other)
KW  - prostate cancer (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35726641
DO  - DOI:10.1093/ije/dyac124
UR  - https://inrepo02.dkfz.de/record/180416
ER  -