TY - JOUR AU - Watts, Eleanor L AU - Perez-Cornago, Aurora AU - Fensom, Georgina K AU - Smith-Byrne, Karl AU - Noor, Urwah AU - Andrews, Colm D AU - Gunter, Marc J AU - Holmes, Michael V AU - Martin, Richard M AU - Tsilidis, Konstantinos K AU - Albanes, Demetrius AU - Barricarte, Aurelio AU - Bueno-de-Mesquita, H Bas AU - Cohn, Barbara A AU - Deschasaux-Tanguy, Melanie AU - Dimou, Niki L AU - Ferrucci, Luigi AU - Flicker, Leon AU - Freedman, Neal D AU - Giles, Graham G AU - Giovannucci, Edward L AU - Haiman, Christopher A AU - Hankey, Graham J AU - Holly, Jeffrey M P AU - Huang, Jiaqi AU - Huang, Wen-Yi AU - Hurwitz, Lauren M AU - Kaaks, Rudolf AU - Kubo, Tatsuhiko AU - Le Marchand, Loic AU - MacInnis, Robert J AU - Männistö, Satu AU - Metter, E Jeffrey AU - Mikami, Kazuya AU - Mucci, Lorelei A AU - Olsen, Anja W AU - Ozasa, Kotaro AU - Palli, Domenico AU - Penney, Kathryn L AU - Platz, Elizabeth A AU - Pollak, Michael N AU - Roobol, Monique J AU - Schaefer, Catherine A AU - Schenk, Jeannette M AU - Stattin, Pär AU - Tamakoshi, Akiko AU - Thysell, Elin AU - Tsai, Chiaojung Jillian AU - Touvier, Mathilde AU - Van Den Eeden, Stephen K AU - Weiderpass, Elisabete AU - Weinstein, Stephanie J AU - Wilkens, Lynne R AU - Yeap, Bu B AU - Allen, Naomi E AU - Key, Timothy J AU - Travis, Ruth C AU - Eeles, Rosalind A AU - Haiman, Christopher A AU - Kote-Jarai, Zsofia AU - Schumacher, Fredrick R AU - Benlloch, Sara AU - Olama, Ali Amin Al AU - Muir, Kenneth R AU - Berndt, Sonja I AU - Conti, David V AU - Wiklund, Fredrik AU - Chanock, Stephen AU - Wang, Ying AU - Tangen, Catherine M AU - Batra, Jyotsna AU - Clements, Judith A TI - Circulating insulin-like growth factors and risks of overall, aggressive and early-onset prostate cancer: a collaborative analysis of 20 prospective studies and Mendelian randomization analysis. JO - International journal of epidemiology VL - 52 IS - 1 SN - 0300-5771 CY - Oxford PB - Oxford Univ. Press M1 - DKFZ-2022-01319 SP - 71-86 PY - 2023 N1 - 2023 Feb 8;52(1):71-86 AB - Previous studies had limited power to assess the associations of circulating insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) with clinically relevant prostate cancer as a primary endpoint, and the association of genetically predicted IGF-I with aggressive prostate cancer is not known. We aimed to investigate the associations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 concentrations with overall, aggressive and early-onset prostate cancer.Prospective analysis of biomarkers using the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset (up to 20 studies, 17 009 prostate cancer cases, including 2332 aggressive cases). Odds ratios (OR) and 95 KW - Insulin-like growth factor-I (Other) KW - Mendelian randomization (Other) KW - aggressive prostate cancer (Other) KW - international consortia (Other) KW - prospective analysis (Other) KW - prostate cancer (Other) LB - PUB:(DE-HGF)16 C6 - pmid:35726641 DO - DOI:10.1093/ije/dyac124 UR - https://inrepo02.dkfz.de/record/180416 ER -