%0 Journal Article %A Nimptsch, Katharina %A Aleksandrova, Krasimira %A Fedirko, Veronika %A Jenab, Mazda %A Gunter, Marc J %A Siersema, Peter D %A Wu, Kana %A Katzke, Verena %A Kaaks, Rudolf %A Panico, Salvatore %A Palli, Domenico %A May, Anne M %A Sieri, Sabina %A Bueno-de-Mesquita, Bas %A Standahl, Karina %A Sánchez, Maria-Jose %A Perez-Cornago, Aurora %A Olsen, Anja %A Tjønneland, Anne %A Bonet, Catalina Bonet %A Dahm, Christina C %A Chirlaque, María-Dolores %A Fiano, Valentina %A Tumino, Rosario %A Gurrea, Aurelio Barricarte %A Boutron-Ruault, Marie-Christine %A Menegaux, Florence %A Severi, Gianluca %A van Guelpen, Bethany %A Lee, Young-Ae %A Pischon, Tobias %T Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations. %J BMC cancer %V 22 %N 1 %@ 1471-2407 %C Heidelberg %I Springer %M DKFZ-2022-01335 %P 695 %D 2022 %X The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear.We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression.During a median follow-up of 9.3 years, 455 CRC-specific deaths were recorded, out of 590 deaths from all causes. Pre-diagnostic CRP concentrations were not associated with CRC-specific (hazard ratio, HR highest versus lowest quintile 0.92, 95 %F PUB:(DE-HGF)16 %9 Journal Article %$ pmid:35739525 %R 10.1186/s12885-022-09778-9 %U https://inrepo02.dkfz.de/record/180440