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000180440 1001_ $$00000-0001-7877-205X$$aNimptsch, Katharina$$b0
000180440 245__ $$aPre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations.
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000180440 520__ $$aThe role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear.We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression.During a median follow-up of 9.3 years, 455 CRC-specific deaths were recorded, out of 590 deaths from all causes. Pre-diagnostic CRP concentrations were not associated with CRC-specific (hazard ratio, HR highest versus lowest quintile 0.92, 95% confidence interval, CI 0.66, 1.28) or all-cause mortality (HR 0.91, 95% CI 0.68, 1.21). Genetic predisposition to higher CRP (weighted score based on alleles of four CRP SNPs associated with higher circulating CRP) was not significantly associated with CRC-specific mortality (HR per CRP-score unit 0.95, 95% CI 0.86, 1.05) or all-cause mortality (HR 0.98, 95% CI 0.90, 1.07). Among four investigated CRP genetic variants, only SNP rs1205 was significantly associated with CRC-specific (comparing the CT and CC genotypes with TT genotype, HR 0.54, 95% CI 0.35, 0.83 and HR 0.58, 95% CI 0.38, 0.88, respectively) and all-cause mortality (HR 0.58, 95% CI 0.40, 0.85 and 0.64, 95% CI 0.44, 0.92, respectively).The results of this prospective cohort study do not support a role of pre-diagnostic CRP concentrations on mortality in individuals with CRC. The observed associations with rs1205 deserve further scientific attention.
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000180440 7001_ $$aAleksandrova, Krasimira$$b1
000180440 7001_ $$aFedirko, Veronika$$b2
000180440 7001_ $$aJenab, Mazda$$b3
000180440 7001_ $$aGunter, Marc J$$b4
000180440 7001_ $$aSiersema, Peter D$$b5
000180440 7001_ $$aWu, Kana$$b6
000180440 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b7$$udkfz
000180440 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b8$$udkfz
000180440 7001_ $$aPanico, Salvatore$$b9
000180440 7001_ $$aPalli, Domenico$$b10
000180440 7001_ $$aMay, Anne M$$b11
000180440 7001_ $$aSieri, Sabina$$b12
000180440 7001_ $$aBueno-de-Mesquita, Bas$$b13
000180440 7001_ $$aStandahl, Karina$$b14
000180440 7001_ $$aSánchez, Maria-Jose$$b15
000180440 7001_ $$aPerez-Cornago, Aurora$$b16
000180440 7001_ $$aOlsen, Anja$$b17
000180440 7001_ $$aTjønneland, Anne$$b18
000180440 7001_ $$aBonet, Catalina Bonet$$b19
000180440 7001_ $$aDahm, Christina C$$b20
000180440 7001_ $$aChirlaque, María-Dolores$$b21
000180440 7001_ $$aFiano, Valentina$$b22
000180440 7001_ $$aTumino, Rosario$$b23
000180440 7001_ $$aGurrea, Aurelio Barricarte$$b24
000180440 7001_ $$aBoutron-Ruault, Marie-Christine$$b25
000180440 7001_ $$aMenegaux, Florence$$b26
000180440 7001_ $$aSeveri, Gianluca$$b27
000180440 7001_ $$avan Guelpen, Bethany$$b28
000180440 7001_ $$aLee, Young-Ae$$b29
000180440 7001_ $$aPischon, Tobias$$b30
000180440 773__ $$0PERI:(DE-600)2041352-X$$a10.1186/s12885-022-09778-9$$gVol. 22, no. 1, p. 695$$n1$$p695$$tBMC cancer$$v22$$x1471-2407$$y2022
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