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@ARTICLE{Nimptsch:180440,
      author       = {K. Nimptsch and K. Aleksandrova and V. Fedirko and M. Jenab
                      and M. J. Gunter and P. D. Siersema and K. Wu and V.
                      Katzke$^*$ and R. Kaaks$^*$ and S. Panico and D. Palli and
                      A. M. May and S. Sieri and B. Bueno-de-Mesquita and K.
                      Standahl and M.-J. Sánchez and A. Perez-Cornago and A.
                      Olsen and A. Tjønneland and C. B. Bonet and C. C. Dahm and
                      M.-D. Chirlaque and V. Fiano and R. Tumino and A. B. Gurrea
                      and M.-C. Boutron-Ruault and F. Menegaux and G. Severi and
                      B. van Guelpen and Y.-A. Lee and T. Pischon},
      title        = {{P}re-diagnostic {C}-reactive protein concentrations, {CRP}
                      genetic variation and mortality among individuals with
                      colorectal cancer in {W}estern {E}uropean populations.},
      journal      = {BMC cancer},
      volume       = {22},
      number       = {1},
      issn         = {1471-2407},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2022-01335},
      pages        = {695},
      year         = {2022},
      abstract     = {The role of elevated pre-diagnostic C-reactive protein
                      (CRP) concentrations on mortality in individuals with
                      colorectal cancer (CRC) remains unclear.We investigated the
                      association between pre-diagnostic high-sensitivity CRP
                      concentrations and CRP genetic variation associated with
                      circulating CRP and CRC-specific and all-cause mortality
                      based on data from 1,235 individuals with CRC within the
                      European Prospective Investigation into Cancer and Nutrition
                      cohort using multivariable-adjusted Cox proportional hazards
                      regression.During a median follow-up of 9.3 years, 455
                      CRC-specific deaths were recorded, out of 590 deaths from
                      all causes. Pre-diagnostic CRP concentrations were not
                      associated with CRC-specific (hazard ratio, HR highest
                      versus lowest quintile 0.92, $95\%$ confidence interval, CI
                      0.66, 1.28) or all-cause mortality (HR 0.91, $95\%$ CI 0.68,
                      1.21). Genetic predisposition to higher CRP (weighted score
                      based on alleles of four CRP SNPs associated with higher
                      circulating CRP) was not significantly associated with
                      CRC-specific mortality (HR per CRP-score unit 0.95, $95\%$
                      CI 0.86, 1.05) or all-cause mortality (HR 0.98, $95\%$ CI
                      0.90, 1.07). Among four investigated CRP genetic variants,
                      only SNP rs1205 was significantly associated with
                      CRC-specific (comparing the CT and CC genotypes with TT
                      genotype, HR 0.54, $95\%$ CI 0.35, 0.83 and HR 0.58, $95\%$
                      CI 0.38, 0.88, respectively) and all-cause mortality (HR
                      0.58, $95\%$ CI 0.40, 0.85 and 0.64, $95\%$ CI 0.44, 0.92,
                      respectively).The results of this prospective cohort study
                      do not support a role of pre-diagnostic CRP concentrations
                      on mortality in individuals with CRC. The observed
                      associations with rs1205 deserve further scientific
                      attention.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35739525},
      doi          = {10.1186/s12885-022-09778-9},
      url          = {https://inrepo02.dkfz.de/record/180440},
}