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@ARTICLE{Geldsetzer:180443,
author = {P. Geldsetzer and T. Mukama$^*$ and N. K. Jawad and T.
Riffe and A. Rogers and N. Sudharsanan},
title = {{S}ex differences in the mortality rate for coronavirus
disease 2019 compared to other causes of death: an analysis
of population-wide data from 63 countries.},
journal = {European journal of epidemiology},
volume = {37},
number = {8},
issn = {0393-2990},
address = {Dordrecht [u.a.]},
publisher = {Springer Science + Business Media B.V.},
reportid = {DKFZ-2022-01338},
pages = {797-806},
year = {2022},
note = {2022 Aug;37(8):797-806},
abstract = {Men are more likely than women to die due to coronavirus
disease 2019 (COVID-19). An open question is whether these
sex differences reflect men's generally poorer health and
lower life expectancy compared to women of similar ages or
if men face a unique COVID-19 disadvantage. Using
age-specific data on COVID-19 mortality as well as
cause-specific and all-cause mortality for 63 countries, we
compared the sex difference in COVID-19 mortality to sex
differences in all-cause mortality and mortality from other
common causes of death to determine the magnitude of the
excess male mortality disadvantage for COVID-19. We found
that sex differences in the age-standardized COVID-19
mortality rate were substantially larger than for the
age-standardized all-cause mortality rate and mortality rate
for most other common causes of death. The excess male
mortality disadvantage for COVID-19 was especially large in
the oldest age groups. Our findings suggest that the causal
pathways that link male sex to a higher mortality from a
SARS-CoV-2 infection may be specific to SARS-CoV-2, rather
than shared with the pathways responsible for the shorter
life expectancy among men or sex differences for other
common causes of death. Understanding these causal chains
could assist in the development of therapeutics and
preventive measures for COVID-19 and, possibly, other
coronavirus diseases.},
keywords = {COVID-19 (Other) / Gender (Other) / Mortality (Other) /
SARS-CoV-2 (Other) / Sex (Other)},
cin = {C020},
ddc = {610},
cid = {I:(DE-He78)C020-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:35737205},
doi = {10.1007/s10654-022-00866-5},
url = {https://inrepo02.dkfz.de/record/180443},
}