%0 Journal Article
%A Spohn, Simon K B
%A Birkenmaier, Viktoria
%A Ruf, Juri
%A Mix, Michael
%A Sigle, August
%A Haehl, Erik
%A Adebahr, Sonja
%A Sprave, Tanja
%A Gkika, Eleni
%A Rühle, Alexander
%A Nicolay, Nils H
%A Kirste, Simon
%A Grosu, Anca L
%A Zamboglou, Constantinos
%T Risk Factors for Biochemical Recurrence After PSMA-PET-Guided Definitive Radiotherapy in Patients With De Novo Lymph Node-Positive Prostate Cancer.
%J Frontiers in oncology
%V 12
%@ 2234-943X
%C Lausanne
%I Frontiers Media
%M DKFZ-2022-01343
%P 898774
%D 2022
%X The National Comprehensive Cancer Network recommends external beam radiotherapy (EBRT) combined with androgen deprivation therapy (ADT) as the preferred treatment option for newly diagnosed node-positive (cN1) prostate cancer (PCa) patients. However, implementation of positron emission tomography targeting prostate-specific membrane antigen (PSMA-PET) in the staging of primary PCa patients has a significant impact on RT treatment concepts. This study aims to evaluate outcomes and their respective risk factors on patients with PSMA-PET-based cN1 and/or cM1a PCa receiving primary RT and ADT.Forty-eight patients with cN0 and/or cM1a PCa staged by [18F]PSMA-1007-PET (n = 19) or [68Ga]PSMA-11-PET (n = 29) were retrospectively included. All patients received EBRT to the pelvis ± boost to positive nodes, followed by boost to the prostate. The impact of different PET-derived characteristics such as maximum standard uptake value (SUVmax) and number of PET-positive lymph nodes on biochemical recurrence-free survival (BRFS) (Phoenix criteria) and metastasis-free survival (MFS) was determined using Kaplan-Meier and Cox proportional hazard regression analyses.Median follow-up was 24 months. Median initial serum prostate-specific antigen was 20.2 ng/ml (IQR 10.2-54.2). Most patients had cT stage ≥ 3 (63
%K PSMA-PET/CT (Other)
%K lymph node positive (Other)
%K personalization (Other)
%K prostate cancer (Other)
%K radiotherapy (Other)
%K risk factors (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35747822
%2 pmc:PMC9209705
%R 10.3389/fonc.2022.898774
%U https://inrepo02.dkfz.de/record/180464