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| Home > Publications database > Risk Factors for Biochemical Recurrence After PSMA-PET-Guided Definitive Radiotherapy in Patients With De Novo Lymph Node-Positive Prostate Cancer. > print |
| 001 | 180464 | ||
| 005 | 20240229145619.0 | ||
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| 100 | 1 | _ | |a Spohn, Simon K B |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Risk Factors for Biochemical Recurrence After PSMA-PET-Guided Definitive Radiotherapy in Patients With De Novo Lymph Node-Positive Prostate Cancer. |
| 260 | _ | _ | |a Lausanne |c 2022 |b Frontiers Media |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1674638153_18725 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The National Comprehensive Cancer Network recommends external beam radiotherapy (EBRT) combined with androgen deprivation therapy (ADT) as the preferred treatment option for newly diagnosed node-positive (cN1) prostate cancer (PCa) patients. However, implementation of positron emission tomography targeting prostate-specific membrane antigen (PSMA-PET) in the staging of primary PCa patients has a significant impact on RT treatment concepts. This study aims to evaluate outcomes and their respective risk factors on patients with PSMA-PET-based cN1 and/or cM1a PCa receiving primary RT and ADT.Forty-eight patients with cN0 and/or cM1a PCa staged by [18F]PSMA-1007-PET (n = 19) or [68Ga]PSMA-11-PET (n = 29) were retrospectively included. All patients received EBRT to the pelvis ± boost to positive nodes, followed by boost to the prostate. The impact of different PET-derived characteristics such as maximum standard uptake value (SUVmax) and number of PET-positive lymph nodes on biochemical recurrence-free survival (BRFS) (Phoenix criteria) and metastasis-free survival (MFS) was determined using Kaplan-Meier and Cox proportional hazard regression analyses.Median follow-up was 24 months. Median initial serum prostate-specific antigen was 20.2 ng/ml (IQR 10.2-54.2). Most patients had cT stage ≥ 3 (63%) and ISUP grade ≥ 3 (85%). Median dose to the prostate, elective nodes, and PET-positive nodes was 75 Gy, 45 Gy, and 55 Gy, respectively. Ninety percent of patients received ADT with a median duration of 9 months (IQR 6-18). In univariate analysis, cM1a stage (p = 0.03), number of >2 pelvic nodes (p = 0.01), number of >1 abdominal node (p = 0.02), and SUVmax values ≥ median (8.1 g/ml for 68Ga-PSMA-11 and 7.9 g/ml for 18F-PSMA-1007) extracted from lymph nodes were significantly associated with unfavorable BRFS, but classical clinicopathological features were not. Number of >2 pelvic nodes (n = 0.03), number of >1 abdominal node (p = 0.03), and SUVmax values ≥ median extracted from lymph nodes were associated with unfavorable MFS. In multivariate analysis, number of >2 pelvic lymph nodes was significantly associated with unfavorable BRFS (HR 5.2, p = 0.01) and SUVmax values ≥ median extracted from lymph nodes had unfavorable MFS (HR 6.3, p = 0.02).More than 2 PET-positive pelvic lymph nodes are associated with unfavorable BRFS, and high SUVmax values are associated with unfavorable MFS. Thus, the number of PET-positive lymph nodes and the SUVmax value might be relevant prognosticators to identify patients with favorable outcomes. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 7 | |a PSMA-PET/CT |2 Other |
| 650 | _ | 7 | |a lymph node positive |2 Other |
| 650 | _ | 7 | |a personalization |2 Other |
| 650 | _ | 7 | |a prostate cancer |2 Other |
| 650 | _ | 7 | |a radiotherapy |2 Other |
| 650 | _ | 7 | |a risk factors |2 Other |
| 700 | 1 | _ | |a Birkenmaier, Viktoria |b 1 |
| 700 | 1 | _ | |a Ruf, Juri |b 2 |
| 700 | 1 | _ | |a Mix, Michael |b 3 |
| 700 | 1 | _ | |a Sigle, August |b 4 |
| 700 | 1 | _ | |a Haehl, Erik |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Adebahr, Sonja |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Sprave, Tanja |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Gkika, Eleni |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Rühle, Alexander |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Nicolay, Nils H |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Kirste, Simon |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Grosu, Anca L |0 P:(DE-HGF)0 |b 12 |
| 700 | 1 | _ | |a Zamboglou, Constantinos |0 P:(DE-HGF)0 |b 13 |
| 773 | _ | _ | |a 10.3389/fonc.2022.898774 |g Vol. 12, p. 898774 |0 PERI:(DE-600)2649216-7 |p 898774 |t Frontiers in oncology |v 12 |y 2022 |x 2234-943X |
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