% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Chen:180479,
      author       = {X. Chen$^*$ and H. Li$^*$ and F. Guo$^*$ and M.
                      Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{A}lcohol consumption, polygenic risk score, and early- and
                      late-onset colorectal cancer risk.},
      journal      = {EClinicalMedicine},
      volume       = {49},
      issn         = {2589-5370},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2022-01358},
      pages        = {101460},
      year         = {2022},
      note         = {#EA:C070#LA:C070#LA:C120#},
      abstract     = {Evidence is lacking on the impact of alcohol consumption on
                      colorectal cancer (CRC) risk (overall and by age at
                      diagnosis) by polygenic risk score (PRS) levels, and it is
                      unclear how the magnitude of CRC risk associated with
                      alcohol consumption compares to the magnitude of genetically
                      determined risk.Multiple logistic regression was used to
                      assess the association between alcohol consumption and
                      colorectal cancer (CRC) across PRS levels based on 140
                      CRC-related loci among 5104 CRC cases and 4131 controls from
                      a large population-based case-control study. We compared the
                      effects for alcohol consumption and PRS on CRC risk using
                      the 'Genetic Risk Equivalent (GRE)' for effective risk
                      communication. Specific analyses were conducted for
                      early-onset CRC (EOCRC, <55 years) and late-onset CRC
                      (LOCRC, ≥55 years).High alcohol consumption, and to a
                      lower extent, also alcohol abstinence were associated with
                      increased CRC risk. Compared to low alcohol consumption
                      (0·1-<25 g/d), lifetime average alcohol consumption ≥25
                      g/d was more strongly associated with EOCRC [odds ratio (OR)
                      1·8, $95\%$ confidence interval (CI) 1·2-2·8] than with
                      LOCRC risk (OR 1·3, $95\%$ CI 1·1-1·4) (P-value for
                      interaction with age =0·011). Interactions between alcohol
                      consumption and PRS did not reach statistical significance
                      for either EOCRC or LOCRC risk. The estimated impact of high
                      lifetime alcohol consumption on EOCRC was equivalent to the
                      effect of having 47 percentiles higher PRS (GRE 47, $95\%$
                      CI 12-82), stronger than the impact on LOCRC (GRE 18, $95\%$
                      CI 8-29).Excessive alcohol use was strongly associated with
                      EOCRC risk, independent of PRS levels. Abstaining from heavy
                      drinking could reduce risk for CRC, in particular for EOCRC
                      to an extent that would be equivalent to having a much lower
                      genetically determined risk.The first author (X.C.) was
                      supported by the Guangzhou Elite Project (GEP). The DACHS
                      study was supported by grants from the German Research
                      Council (BR 1704/6-1, BR1704/6-3, BR 1704/6-4, BR 1704/6-6,
                      CH 117/1-1, BR 1704/17-1, HO 5117/2-1) and the German
                      Federal Ministry of Education and Research (01KH0404,
                      01ER0814, 01ER0815, 01GL1712).},
      keywords     = {Alcohol consumption (Other) / CI, confidence interval
                      (Other) / CRC, colorectal cancer (Other) / DACHS, Darmkrebs:
                      Chancen der Verhütung durch Screening (Other) / EOCRC,
                      early-onset colorectal cancer (Other) / Early-onset
                      colorectal cancer (Other) / GRE, genetic risk equivalent
                      (Other) / GWAS, genome-wide association study (Other) /
                      Genetic risk equivalentt (Other) / LOCRC, late-onset
                      colorectal cancer (Other) / Late-onset colorectal cancer
                      (Other) / NSAID, non-steroidal anti-inflammatory drug
                      (Other) / OR, odds ratio (Other) / PRS, polygenic risk score
                      (Other) / Polygenic risk score (Other) / SNP, single
                      nucleotide polymorphisms (Other)},
      cin          = {C070 / HD01 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35747198},
      pmc          = {pmc:PMC9126769},
      doi          = {10.1016/j.eclinm.2022.101460},
      url          = {https://inrepo02.dkfz.de/record/180479},
}