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000180480 1001_ $$00000-0001-7646-7967$$aPeluso, Marco$$b0
000180480 245__ $$aCruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort).
000180480 260__ $$aBasel$$bMDPI$$c2022
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000180480 520__ $$aEpidemiologic studies have indicated that cruciferous vegetables can influence the cancer risk; therefore, we examined with a cross-sectional approach the correlation between the frequent consumption of the total cruciferous vegetables and the formation of bulky DNA damage, a biomarker of carcinogen exposure and cancer risk, in the Gen-Air study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. DNA damage measurements were performed in the peripheral blood of 696 of those apparently healthy without cancer controls, including 379 never-smokers and 317 former smokers from seven European countries by the 32P-postlabeling assay. In the Gen-Air controls, the median intake of cruciferous vegetables was 6.16 (IQR 1.16-13.66) g/day, ranging from 0.37 (IQR 0-6.00) g/day in Spain to 11.34 (IQR 6.02-16.07) g/day in the UK. Based on this information, participants were grouped into: (a) high consumers (>20 g/day), (b) medium consumers (3-20 g/day) and (c) low consumers (<3.0 g/day). Overall, low cruciferous vegetable intake was correlated with a greater frequency of bulky DNA lesions, including benzo(a)pyrene, lactone and quinone-adducts and bulky oxidative lesions, in the adjusted models. Conversely, a high versus low intake of cruciferous vegetables was associated with a reduction in DNA damage (up to a 23% change, p = 0.032); this was particularly evident in former smokers (up to a 40% change, p = 0.008). The Generalized Linear Regression models indicated an overall Mean Ratio between the high and the low consumers of 0.78 (95% confidence interval, 0.64-0.97). The current study suggests that a higher intake of cruciferous vegetables is associated with a lower level of bulky DNA adducts and supports the potential for cancer prevention strategies through dietary habit changes aimed at increasing the consumption of cruciferous vegetables.
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000180480 650_7 $$2Other$$aB(a)P-adducts
000180480 650_7 $$2Other$$aDNA damage
000180480 650_7 $$2Other$$aEPIC
000180480 650_7 $$2Other$$abulky oxidative lesions
000180480 650_7 $$2Other$$acruciferous vegetables
000180480 650_7 $$2Other$$adiet
000180480 7001_ $$aMunnia, Armelle$$b1
000180480 7001_ $$00000-0002-5826-2455$$aRusso, Valentina$$b2
000180480 7001_ $$aGalli, Andrea$$b3
000180480 7001_ $$00000-0001-5438-970X$$aPala, Valeria$$b4
000180480 7001_ $$00000-0002-4605-435X$$aSchouw, Yvonne T van der$$b5
000180480 7001_ $$00000-0002-0830-5277$$aSchulze, Matthias B$$b6
000180480 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b7
000180480 7001_ $$aTumino, Rosario$$b8
000180480 7001_ $$00000-0002-0117-1608$$aSaieva, Calogero$$b9
000180480 7001_ $$aExezarreta Pilar, Amiano$$b10
000180480 7001_ $$00000-0002-4533-1722$$aAune, Dagfinn$$b11
000180480 7001_ $$00000-0001-6517-1300$$aHeath, Alicia K$$b12
000180480 7001_ $$00000-0002-0442-3284$$aAglago, Elom$$b13
000180480 7001_ $$aAgudo, Antonio$$b14
000180480 7001_ $$aPanico, Salvatore$$b15
000180480 7001_ $$aPetersen, Kristina Elin Nielsen$$b16
000180480 7001_ $$00000-0003-4385-2097$$aTjønneland, Anne$$b17
000180480 7001_ $$00000-0001-6541-0308$$aCirera, Lluís$$b18
000180480 7001_ $$00000-0002-9972-9779$$aRodriguez-Barranco, Miguel$$b19
000180480 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b20$$udkfz
000180480 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b21$$udkfz
000180480 7001_ $$00000-0001-8749-9737$$aRicceri, Fulvio$$b22
000180480 7001_ $$00000-0002-2185-2179$$aMilani, Lorenzo$$b23
000180480 7001_ $$aVineis, Paolo$$b24
000180480 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b25
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