TY  - JOUR
AU  - Peluso, Marco
AU  - Munnia, Armelle
AU  - Russo, Valentina
AU  - Galli, Andrea
AU  - Pala, Valeria
AU  - Schouw, Yvonne T van der
AU  - Schulze, Matthias B
AU  - Weiderpass, Elisabete
AU  - Tumino, Rosario
AU  - Saieva, Calogero
AU  - Exezarreta Pilar, Amiano
AU  - Aune, Dagfinn
AU  - Heath, Alicia K
AU  - Aglago, Elom
AU  - Agudo, Antonio
AU  - Panico, Salvatore
AU  - Petersen, Kristina Elin Nielsen
AU  - Tjønneland, Anne
AU  - Cirera, Lluís
AU  - Rodriguez-Barranco, Miguel
AU  - Katzke, Verena
AU  - Kaaks, Rudolf
AU  - Ricceri, Fulvio
AU  - Milani, Lorenzo
AU  - Vineis, Paolo
AU  - Sacerdote, Carlotta
TI  - Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort).
JO  - Nutrients
VL  - 14
IS  - 12
SN  - 2072-6643
CY  - Basel
PB  - MDPI
M1  - DKFZ-2022-01359
SP  - 2477
PY  - 2022
AB  - Epidemiologic studies have indicated that cruciferous vegetables can influence the cancer risk; therefore, we examined with a cross-sectional approach the correlation between the frequent consumption of the total cruciferous vegetables and the formation of bulky DNA damage, a biomarker of carcinogen exposure and cancer risk, in the Gen-Air study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. DNA damage measurements were performed in the peripheral blood of 696 of those apparently healthy without cancer controls, including 379 never-smokers and 317 former smokers from seven European countries by the 32P-postlabeling assay. In the Gen-Air controls, the median intake of cruciferous vegetables was 6.16 (IQR 1.16-13.66) g/day, ranging from 0.37 (IQR 0-6.00) g/day in Spain to 11.34 (IQR 6.02-16.07) g/day in the UK. Based on this information, participants were grouped into: (a) high consumers (>20 g/day), (b) medium consumers (3-20 g/day) and (c) low consumers (<3.0 g/day). Overall, low cruciferous vegetable intake was correlated with a greater frequency of bulky DNA lesions, including benzo(a)pyrene, lactone and quinone-adducts and bulky oxidative lesions, in the adjusted models. Conversely, a high versus low intake of cruciferous vegetables was associated with a reduction in DNA damage (up to a 23
KW  - B(a)P-adducts (Other)
KW  - DNA damage (Other)
KW  - EPIC (Other)
KW  - bulky oxidative lesions (Other)
KW  - cruciferous vegetables (Other)
KW  - diet (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35745207
DO  - DOI:10.3390/nu14122477
UR  - https://inrepo02.dkfz.de/record/180480
ER  -