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@ARTICLE{Peluso:180480,
      author       = {M. Peluso and A. Munnia and V. Russo and A. Galli and V.
                      Pala and Y. T. v. d. Schouw and M. B. Schulze and E.
                      Weiderpass and R. Tumino and C. Saieva and A. Exezarreta
                      Pilar and D. Aune and A. K. Heath and E. Aglago and A. Agudo
                      and S. Panico and K. E. N. Petersen and A. Tjønneland and
                      L. Cirera and M. Rodriguez-Barranco and V. Katzke$^*$ and R.
                      Kaaks$^*$ and F. Ricceri and L. Milani and P. Vineis and C.
                      Sacerdote},
      title        = {{C}ruciferous {V}egetable {I}ntake and {B}ulky {DNA}
                      {D}amage within {N}on-{S}mokers and {F}ormer {S}mokers in
                      the {G}en-{A}ir {S}tudy ({EPIC} {C}ohort).},
      journal      = {Nutrients},
      volume       = {14},
      number       = {12},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2022-01359},
      pages        = {2477},
      year         = {2022},
      abstract     = {Epidemiologic studies have indicated that cruciferous
                      vegetables can influence the cancer risk; therefore, we
                      examined with a cross-sectional approach the correlation
                      between the frequent consumption of the total cruciferous
                      vegetables and the formation of bulky DNA damage, a
                      biomarker of carcinogen exposure and cancer risk, in the
                      Gen-Air study within the European Prospective Investigation
                      into Cancer and Nutrition (EPIC) cohort. DNA damage
                      measurements were performed in the peripheral blood of 696
                      of those apparently healthy without cancer controls,
                      including 379 never-smokers and 317 former smokers from
                      seven European countries by the 32P-postlabeling assay. In
                      the Gen-Air controls, the median intake of cruciferous
                      vegetables was 6.16 (IQR 1.16-13.66) g/day, ranging from
                      0.37 (IQR 0-6.00) g/day in Spain to 11.34 (IQR 6.02-16.07)
                      g/day in the UK. Based on this information, participants
                      were grouped into: (a) high consumers (>20 g/day), (b)
                      medium consumers (3-20 g/day) and (c) low consumers (<3.0
                      g/day). Overall, low cruciferous vegetable intake was
                      correlated with a greater frequency of bulky DNA lesions,
                      including benzo(a)pyrene, lactone and quinone-adducts and
                      bulky oxidative lesions, in the adjusted models. Conversely,
                      a high versus low intake of cruciferous vegetables was
                      associated with a reduction in DNA damage (up to a $23\%$
                      change, p = 0.032); this was particularly evident in former
                      smokers (up to a $40\%$ change, p = 0.008). The Generalized
                      Linear Regression models indicated an overall Mean Ratio
                      between the high and the low consumers of 0.78 $(95\%$
                      confidence interval, 0.64-0.97). The current study suggests
                      that a higher intake of cruciferous vegetables is associated
                      with a lower level of bulky DNA adducts and supports the
                      potential for cancer prevention strategies through dietary
                      habit changes aimed at increasing the consumption of
                      cruciferous vegetables.},
      keywords     = {B(a)P-adducts (Other) / DNA damage (Other) / EPIC (Other) /
                      bulky oxidative lesions (Other) / cruciferous vegetables
                      (Other) / diet (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35745207},
      doi          = {10.3390/nu14122477},
      url          = {https://inrepo02.dkfz.de/record/180480},
}