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000180485 1001_ $$0P:(DE-HGF)0$$aPatil, Shivaprasad$$b0
000180485 245__ $$aA Novel 2-Metagene Signature to Identify High-Risk HNSCC Patients amongst Those Who Are Clinically at Intermediate Risk and Are Treated with PORT.
000180485 260__ $$aBasel$$bMDPI$$c2022
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000180485 520__ $$a(1) Background: Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) who are biologically at high risk for the development of loco-regional recurrences after postoperative radiotherapy (PORT) but at intermediate risk according to clinical risk factors may benefit from additional concurrent chemotherapy. In this matched-pair study, we aimed to identify a corresponding predictive gene signature. (2) Methods: Gene expression analysis was performed on a multicenter retrospective cohort of 221 patients that were treated with postoperative radiochemotherapy (PORT-C) and 283 patients who were treated with PORT alone. Propensity score analysis was used to identify matched patient pairs from both cohorts. From differential gene expression analysis and Cox regression, a predictive gene signature was identified. (3) Results: 108 matched patient pairs were selected. We identified a 2-metagene signature that stratified patients into risk groups in both cohorts. The comparison of the high-risk patients between the two types of treatment showed higher loco-regional control (LRC) after treatment with PORT-C (p < 0.001), which was confirmed by a significant interaction term in Cox regression (p = 0.027), i.e., the 2-metagene signature was indicative for the type of treatment. (4) Conclusion: We have identified a novel gene signature that may be helpful to identify patients with high-risk HNSCC amongst those at intermediate clinical risk treated with PORT, who may benefit from additional concurrent chemotherapy.
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000180485 650_7 $$2Other$$agene signature
000180485 650_7 $$2Other$$ahead and neck squamous cell carcinoma
000180485 650_7 $$2Other$$apostoperative radiochemotherapy
000180485 650_7 $$2Other$$apostoperative radiotherapy
000180485 650_7 $$2Other$$apropensity score matching
000180485 7001_ $$0P:(DE-He78)81b719227985a27b1b77ed6766094319$$aLinge, Annett$$b1
000180485 7001_ $$aHiepe, Hannah$$b2
000180485 7001_ $$00000-0001-9865-208X$$aGrosser, Marianne$$b3
000180485 7001_ $$0P:(DE-HGF)0$$aLohaus, Fabian$$b4
000180485 7001_ $$aGudziol, Volker$$b5
000180485 7001_ $$aKemper, Max$$b6
000180485 7001_ $$aNowak, Alexander$$b7
000180485 7001_ $$aHaim, Dominik$$b8
000180485 7001_ $$0P:(DE-HGF)0$$aTinhofer, Inge$$b9
000180485 7001_ $$0P:(DE-HGF)0$$aBudach, Volker$$b10
000180485 7001_ $$00000-0003-3218-0539$$aGuberina, Maja$$b11
000180485 7001_ $$0P:(DE-HGF)0$$aStuschke, Martin$$b12
000180485 7001_ $$00000-0001-5261-6446$$aBalermpas, Panagiotis$$b13
000180485 7001_ $$00000-0002-9371-7814$$aGrün, Jens von der$$b14
000180485 7001_ $$00000-0002-5948-5095$$aSchäfer, Henning$$b15
000180485 7001_ $$0P:(DE-HGF)0$$aGrosu, Anca-Ligia$$b16
000180485 7001_ $$0P:(DE-He78)360c5bc2b71a849e35aca747c041dda7$$aAbdollahi, Amir$$b17$$udkfz
000180485 7001_ $$0P:(DE-He78)8714da4e45acfa36ce87c291443a9218$$aDebus, Jürgen$$b18$$udkfz
000180485 7001_ $$0P:(DE-HGF)0$$aGanswindt, Ute$$b19
000180485 7001_ $$0P:(DE-HGF)0$$aBelka, Claus$$b20
000180485 7001_ $$00000-0001-9824-4828$$aPigorsch, Steffi$$b21
000180485 7001_ $$0P:(DE-HGF)0$$aCombs, Stephanie E$$b22
000180485 7001_ $$0P:(DE-HGF)0$$aBoeke, Simon$$b23
000180485 7001_ $$0P:(DE-HGF)0$$aZips, Daniel$$b24
000180485 7001_ $$0P:(DE-HGF)0$$aJöhrens, Korinna$$b25
000180485 7001_ $$0P:(DE-HGF)0$$aBaretton, Gustavo B$$b26
000180485 7001_ $$0P:(DE-He78)933f7d725ac87378f459623783585a1f$$aBaumann, Michael$$b27$$udkfz
000180485 7001_ $$0P:(DE-He78)4be9ccb23f3e472b97743845cd2b3fe9$$aKrause, Mechthild$$b28$$udkfz
000180485 7001_ $$00000-0002-7017-3738$$aLöck, Steffen$$b29
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