% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Kramer:180487,
      author       = {C. S. Kramer$^*$ and L. Greiner$^*$ and K. Kopka and M.
                      Schäfer$^*$},
      title        = {{F}luorination of silyl prosthetic groups by fluorine
                      mediated silyl ether linker cleavage: a concept study with
                      conditions applicable in radiofluorination.},
      journal      = {EJNMMI radiopharmacy and chemistry},
      volume       = {7},
      number       = {1},
      issn         = {2365-421X},
      address      = {[Heidelberg]},
      publisher    = {SpringerOpen},
      reportid     = {DKFZ-2022-01366},
      pages        = {15},
      year         = {2022},
      note         = {#EA:E030#LA:E030#},
      abstract     = {Positron emission tomography (PET) is a powerful tool in
                      medical imaging, especially in combination with the PET
                      radionuclide fluorine-18 that possesses optimal
                      characteristics. For labelling of biomolecules and
                      low-molecular weight tracers, fluorine-18 can be covalently
                      bound to silicon by either nucleophilic replacements of
                      leaving groups (like ethers) or by isotope exchange of
                      fluorine-19. While nucleophilic substitutions require
                      additional purification steps for the removal of
                      contaminants, isotope exchange with fluorine-18 results in
                      low molar activity. Both challenges can be addressed with a
                      detagging-fluorination of an immobilized silyl ether
                      motif.By overcoming the susceptibility towards hydrolysis,
                      optimized detagging conditions (improved reaction time,
                      fluorination reagent, linker, and resin) could afford the
                      highly sterically hindered silyl fluoride motifs, that are
                      commonly applied in radiochemistry in small and
                      semipreparative scales. The described reaction conditions
                      with fluorine-19 are transferrable to conditions with
                      [18F]fluoride and silyl fluorides were obtained after
                      approx. 10 min reaction time and in high-purity after
                      mechanical filtration.We present a proof-of-concept study
                      for a detagging-fluorination of two silyl ethers that are
                      bound to an optimized amino alcohol resin. We show with our
                      model substrate that our solid-phase linker combination is
                      capable of yielding the desired silicon fluoride in amounts
                      sufficient for biological studies in animals or humans under
                      standard fluorination conditions that may also be
                      transferred to a radiolabelling setting. In conclusion, our
                      presented approach could optimize the molar activity and
                      simplify the preparation of radiofluorinated silyl
                      fluorides.},
      keywords     = {Detagging (Other) / Fluorine-18 (Other) / PET (Other) /
                      Radiofluorination (Other) / SiFA (Other) / Silyl fluorides
                      (Other) / Solid phase synthesis (Other) / Solid support
                      (Other)},
      cin          = {E030},
      ddc          = {610},
      cid          = {I:(DE-He78)E030-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35751707},
      doi          = {10.1186/s41181-022-00167-y},
      url          = {https://inrepo02.dkfz.de/record/180487},
}