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000180561 0247_ $$2doi$$a10.1016/j.clnu.2022.05.020
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000180561 037__ $$aDKFZ-2022-01406
000180561 041__ $$aEnglish
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000180561 1001_ $$aWedekind, Roland$$b0
000180561 245__ $$aDeterminants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition.
000180561 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2022
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000180561 520__ $$aCirculating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to influence AC concentrations but a better understanding of their biological, lifestyle and metabolic determinants is needed.Circulating ACs were measured in blood by targeted (15 ACs) and untargeted metabolomics (50 ACs) in 7770 and 395 healthy participants of the European Prospective Investigation into Cancer and Nutrition (EPIC), respectively. Associations with biological and lifestyle characteristics, dietary patterns, self-reported intake of individual foods, estimated intake of carnitine and fatty acids, and fatty acids in plasma phospholipid fraction and amino acids in blood were assessed.Age, sex and fasting status were associated with the largest proportion of AC variability (partial-r up to 0.19, 0.18 and 0.16, respectively). Some AC species of medium or long-chain fatty acid moiety were associated with the corresponding fatty acids in plasma (partial-r = 0.24) or with intake of specific foods such as dairy foods containing the same fatty acid. ACs of short-chain fatty acid moiety (propionylcarnitine and valerylcarnitine) were moderately associated with concentrations of branched-chain amino acids (partial-r = 0.5). Intake of most other foods and of carnitine showed little association with AC levels.Our results show that determinants of ACs in blood vary according to their fatty acid moiety, and that their concentrations are related to age, sex, diet, and fasting status. Knowledge on their potential determinants may help interpret associations of ACs with disease risk and inform on potential dietary and lifestyle factors that might be modified for disease prevention.
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000180561 650_7 $$2Other$$aAcylcarnitines
000180561 650_7 $$2Other$$aBranched-chain amino acids
000180561 650_7 $$2Other$$aDiet
000180561 650_7 $$2Other$$aFatty acids
000180561 650_7 $$2Other$$aMetabolomics
000180561 7001_ $$aRothwell, Joseph A$$b1
000180561 7001_ $$aViallon, Vivian$$b2
000180561 7001_ $$aKeski-Rahkonen, Pekka$$b3
000180561 7001_ $$aSchmidt, Julie A$$b4
000180561 7001_ $$aChajes, Veronique$$b5
000180561 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b6$$udkfz
000180561 7001_ $$0P:(DE-He78)79ab945544e5bc017a2317b6146ed3aa$$aJohnson, Theron$$b7
000180561 7001_ $$aSantucci de Magistris, Maria$$b8
000180561 7001_ $$aKrogh, Vittorio$$b9
000180561 7001_ $$aAmiano, Pilar$$b10
000180561 7001_ $$aSacerdote, Carlotta$$b11
000180561 7001_ $$aRedondo-Sánchez, Daniel$$b12
000180561 7001_ $$aHuerta, José María$$b13
000180561 7001_ $$aTjønneland, Anne$$b14
000180561 7001_ $$aPokharel, Pratik$$b15
000180561 7001_ $$aJakszyn, Paula$$b16
000180561 7001_ $$aTumino, Rosario$$b17
000180561 7001_ $$aArdanaz, Eva$$b18
000180561 7001_ $$aSandanger, Torkjel M$$b19
000180561 7001_ $$aWinkvist, Anna$$b20
000180561 7001_ $$aHultdin, Johan$$b21
000180561 7001_ $$aSchulze, Matthias B$$b22
000180561 7001_ $$aWeiderpass, Elisabete$$b23
000180561 7001_ $$aGunter, Marc J$$b24
000180561 7001_ $$aHuybrechts, Inge$$b25
000180561 7001_ $$aScalbert, Augustin$$b26
000180561 773__ $$0PERI:(DE-600)2009052-3$$a10.1016/j.clnu.2022.05.020$$gVol. 41, no. 8, p. 1735 - 1745$$n8$$p1735 - 1745$$tClinical nutrition$$v41$$x0261-5614$$y2022
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