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@ARTICLE{Wedekind:180561,
      author       = {R. Wedekind and J. A. Rothwell and V. Viallon and P.
                      Keski-Rahkonen and J. A. Schmidt and V. Chajes and V.
                      Katzke$^*$ and T. Johnson$^*$ and M. Santucci de Magistris
                      and V. Krogh and P. Amiano and C. Sacerdote and D.
                      Redondo-Sánchez and J. M. Huerta and A. Tjønneland and P.
                      Pokharel and P. Jakszyn and R. Tumino and E. Ardanaz and T.
                      M. Sandanger and A. Winkvist and J. Hultdin and M. B.
                      Schulze and E. Weiderpass and M. J. Gunter and I. Huybrechts
                      and A. Scalbert},
      title        = {{D}eterminants of blood acylcarnitine concentrations in
                      healthy individuals of the {E}uropean {P}rospective
                      {I}nvestigation into {C}ancer and {N}utrition.},
      journal      = {Clinical nutrition},
      volume       = {41},
      number       = {8},
      issn         = {0261-5614},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2022-01406},
      pages        = {1735 - 1745},
      year         = {2022},
      abstract     = {Circulating levels of acylcarnitines (ACs) have been
                      associated with the risk of various diseases such as cancer
                      and type 2 diabetes. Diet and lifestyle factors have been
                      shown to influence AC concentrations but a better
                      understanding of their biological, lifestyle and metabolic
                      determinants is needed.Circulating ACs were measured in
                      blood by targeted (15 ACs) and untargeted metabolomics (50
                      ACs) in 7770 and 395 healthy participants of the European
                      Prospective Investigation into Cancer and Nutrition (EPIC),
                      respectively. Associations with biological and lifestyle
                      characteristics, dietary patterns, self-reported intake of
                      individual foods, estimated intake of carnitine and fatty
                      acids, and fatty acids in plasma phospholipid fraction and
                      amino acids in blood were assessed.Age, sex and fasting
                      status were associated with the largest proportion of AC
                      variability (partial-r up to 0.19, 0.18 and 0.16,
                      respectively). Some AC species of medium or long-chain fatty
                      acid moiety were associated with the corresponding fatty
                      acids in plasma (partial-r = 0.24) or with intake of
                      specific foods such as dairy foods containing the same fatty
                      acid. ACs of short-chain fatty acid moiety
                      (propionylcarnitine and valerylcarnitine) were moderately
                      associated with concentrations of branched-chain amino acids
                      (partial-r = 0.5). Intake of most other foods and of
                      carnitine showed little association with AC levels.Our
                      results show that determinants of ACs in blood vary
                      according to their fatty acid moiety, and that their
                      concentrations are related to age, sex, diet, and fasting
                      status. Knowledge on their potential determinants may help
                      interpret associations of ACs with disease risk and inform
                      on potential dietary and lifestyle factors that might be
                      modified for disease prevention.},
      keywords     = {Acylcarnitines (Other) / Branched-chain amino acids (Other)
                      / Diet (Other) / Fatty acids (Other) / Metabolomics (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35779425},
      doi          = {10.1016/j.clnu.2022.05.020},
      url          = {https://inrepo02.dkfz.de/record/180561},
}