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000180632 1001_ $$0P:(DE-He78)cbbd83b83a83176c38ba2c45ac072a3d$$aHeld, Thomas$$b0$$eFirst author
000180632 245__ $$aWays to unravel the clinical potential of carbon ions for head and neck cancer reirradiation: dosimetric comparison and local failure pattern analysis as part of the prospective randomized CARE trial.
000180632 260__ $$aLondon$$bBioMed Central$$c2022
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000180632 520__ $$aCarbon ion radiotherapy (CIRT) yields biophysical advantages compared to photons but randomized studies for the reirradiation setting are pending. The aim of the current project was to evaluate potential clinical benefits and drawbacks of CIRT compared to volumetric modulated arc therapy (VMAT) in recurrent head and neck cancer.Dose-volume parameters and local failure patterns of CIRT compared to VMAT were evaluate in 16 patients from the randomized CARE trial on head and neck cancer reirradiation.Despite an increased target dose, CIRT resulted in significantly reduced organ at risk (OAR) dose across all patients (- 8.7% Dmean). The dose-volume benefits were most pronounced in the brainstem (- 20.7% Dmax) and the optic chiasma (- 13.0% Dmax). The most frequent local failure was type E (extraneous; 50%), followed type B (peripheral; 33%) and type A (central; 17%). In one patient with type A biological and/or dosimetric failure after CIRT, mMKM dose recalculation revealed reduced target coverage.CIRT resulted in highly improved critical OAR sparing compared to VMAT across all head and neck cancer reirradiation scenarios despite an increased prescription dose. Local failure pattern analysis revealed further potential CIRT specific clinical benefits and potential pitfalls with regard to image-guidance and biological dose-optimization.
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000180632 650_7 $$2Other$$aCarbon ion radiotherapy
000180632 650_7 $$2Other$$aDosimetric analysis
000180632 650_7 $$2Other$$aHead and neck cancer
000180632 650_7 $$2Other$$aHeavy ions
000180632 650_7 $$2Other$$aLocal control
000180632 650_7 $$2Other$$aPattern of failure
000180632 650_7 $$2Other$$aRe-radiotherapy
000180632 650_7 $$2Other$$aReirradiation
000180632 650_7 $$2Other$$aSquamous cell carcinoma
000180632 650_7 $$2Other$$aVMAT
000180632 7001_ $$0P:(DE-He78)b907c008f5a279f1f3539ca77ec858dc$$aTessonnier, Thomas$$b1$$udkfz
000180632 7001_ $$aFranke, Henrik$$b2
000180632 7001_ $$aRegnery, Sebastian$$b3
000180632 7001_ $$aBauer, Lukas$$b4
000180632 7001_ $$aWeusthof, Katharina$$b5
000180632 7001_ $$0P:(DE-HGF)0$$aHarrabi, Semi$$b6
000180632 7001_ $$0P:(DE-He78)ea5c703d5f5cf5f1c26a34b38a5056dc$$aHerfarth, Klaus$$b7
000180632 7001_ $$0P:(DE-He78)8d6c2aceda79e88defe1e8c0fcc39d59$$aMairani, Andrea$$b8$$udkfz
000180632 7001_ $$0P:(DE-He78)8714da4e45acfa36ce87c291443a9218$$aDebus, Jürgen$$b9$$udkfz
000180632 7001_ $$0P:(DE-HGF)0$$aAdeberg, Sebastian$$b10$$eLast author
000180632 773__ $$0PERI:(DE-600)2224965-5$$a10.1186/s13014-022-02093-4$$gVol. 17, no. 1, p. 121$$n1$$p121$$tRadiation oncology$$v17$$x1748-717X$$y2022
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