%0 Journal Article
%A Barnett, Gillian C
%A Kerns, Sarah L
%A Dorling, Leila
%A Fachal, Laura
%A Aguado-Barrera, Miguel E
%A Martínez-Calvo, Laura
%A Jandu, Harkeran K
%A Welsh, Ceilidh
%A Tyrer, Jonathan
%A Coles, Charlotte E
%A Haviland, Joanne S
%A Parker, Christopher
%A Gómez-Caamaño, Antonio
%A Calvo-Crespo, Patricia
%A Sosa-Fajardo, Paloma
%A Burnet, Neil G
%A Summersgill, Holly
%A Webb, Adam
%A De Ruysscher, Dirk
%A Seibold, Petra
%A Chang-Claude, Jenny
%A Talbot, Christopher J
%A Rattay, Tim
%A Parliament, Matthew
%A De Ruyck, Kim
%A Rosenstein, Barry S
%A Pharoah, Paul D P
%A Dunning, Alison M
%A Vega, Ana
%A West, Catharine M L
%T No association between polygenic risk scores for cancer and development of radiotherapy toxicity.
%J International journal of radiation oncology, biology, physics
%V 114
%N 3
%@ 0360-3016
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2022-01495
%P 494-501
%D 2022
%Z  2022 Nov 1;114(3):494-501
%X To test whether updated polygenic risk scores (PRS) for susceptibility to cancer affect risk of radiotherapy toxicity.Analyses included 9,717 patients with breast (n=3,078), prostate (n=5,748) or lung (n=891) cancer from XXXX and XXXX Consortia cohorts. Patients underwent potentially curative radiotherapy and were assessed prospectively for toxicity. Germline genotyping involved genome-wide single nucleotide polymorphism (SNP) arrays with non-typed SNPs imputed. PRS for each cancer were generated by summing literature-identified cancer susceptibility risk alleles: 352 breast, 136 prostate, 24 lung. Weighted PRS were generated using log odds ratios for cancer susceptibility. Standardized total average toxicity (STAT) scores at 2 and 5 years (breast, prostate) or 6 to 12 months (lung) quantified toxicity. Primary analysis tested late STAT, secondary analyses investigated acute STAT, and individual endpoints and SNPs using multivariable regression.Increasing PRS did not increase risk of late toxicity in patients with breast (OR 1.000, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35840111
%R 10.1016/j.ijrobp.2022.06.098
%U https://inrepo02.dkfz.de/record/180699