TY  - JOUR
AU  - Smith-Byrne, Karl
AU  - Cerani, Agustin
AU  - Guida, Florence
AU  - Zhou, Sirui
AU  - Agudo, Antonio
AU  - Aleksandrova, Krasimira
AU  - Barricarte, Aurelio
AU  - Rodríguez-Barranco, Miguel
AU  - Borchers, Christoph H
AU  - Gram, Inger T
AU  - Han, Jun
AU  - Amos, Christopher I
AU  - Hung, Rayjean J
AU  - Grankvist, Kjell
AU  - Nøst, Therese H
AU  - Imaz, Liher
AU  - Chirlaque-López, María Dolores
AU  - Johansson, Mikael
AU  - Kaaks, Rudolf
AU  - Kühn, Tilman
AU  - Martin, Richard M
AU  - McKay, James D
AU  - Pala, Valeria
AU  - Robbins, Hilary A
AU  - Sandanger, Torkjel M
AU  - Schibli, David
AU  - Schulze, Matthias B
AU  - Travis, Ruth C
AU  - Vineis, Paolo
AU  - Weiderpass, Elisabete
AU  - Brennan, Paul
AU  - Johansson, Mattias
AU  - Richards, J Brent
TI  - Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Pre-Diagnostic Blood Measurements.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 31
IS  - 10
SN  - 1055-9965
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2022-01496
SP  - 1966-1974
PY  - 2022
N1  -  2022 Oct 4;31(10):1966-1974
AB  - Tobacco exposure causes 8 of 10 lung cancers, and identifying additional risk factors is challenging due to confounding introduced by smoking in traditional observational studies.We used Mendelian randomization (MR) to screen 207 metabolites for their role in lung cancer predisposition using independent genome-wide-association studies (GWAS) of blood metabolite levels (n =7,824) and lung cancer risk (n=29,266 cases / 56,450 controls). A nested case control study (656 cases and 1,309 matched controls) was subsequently performed using pre-diagnostic blood samples to validate MR association with lung cancer incidence data from population-based cohorts (EPIC and NSHDS).An MR-based scan of 207 circulating metabolites for lung cancer risk identified that blood isovalerylcarnitine (IVC) was associated with a decreased odds of lung cancer after accounting for multiple testing (Log10-OR = 0.43, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:35839461
DO  - DOI:10.1158/1055-9965.EPI-21-1033
UR  - https://inrepo02.dkfz.de/record/180700
ER  -