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@ARTICLE{Wehrse:180773,
      author       = {E. Wehrse$^*$ and L. Klein$^*$ and L. T. Rotkopf$^*$ and W.
                      Stiller and M. Finke and G. Echner$^*$ and C. Glowa$^*$ and
                      S. Heinze and C. Ziener$^*$ and H.-P. Schlemmer$^*$ and M.
                      Kachelriess$^*$ and S. Sawall$^*$},
      title        = {{U}ltrahigh resolution whole body photon counting computed
                      tomography as a novel versatile tool for translational
                      research from mouse to man.},
      journal      = {Zeitschrift für medizinische Physik},
      volume       = {33},
      number       = {2},
      issn         = {0939-3889},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2022-01538},
      pages        = {155-167},
      year         = {2023},
      note         = {#EA:E010#LA:E025# / 2023 May;33(2):155-167},
      abstract     = {X-ray computed tomography (CT) is a cardinal tool in
                      clinical practice. It provides cross-sectional images within
                      seconds. The recent introduction of clinical photon-counting
                      CT allowed for an increase in spatial resolution by more
                      than a factor of two resulting in a pixel size in the center
                      of rotation of about 150 µm. This level of spatial
                      resolution is in the order of dedicated preclinical micro-CT
                      systems. However so far, the need for different dedicated
                      clinical and preclinical systems often hinders the rapid
                      translation of early research results to applications in
                      men. This drawback might be overcome by ultra-high
                      resolution (UHR) clinical photon-counting CT unifying
                      preclinical and clinical research capabilities in a single
                      machine. Herein, the prototype of a clinical UHR PCD CT
                      (SOMATOM CounT, Siemens Healthineers, Forchheim, Germany)
                      was used. The system comprises a conventional
                      energy-integrating detector (EID) and a novel
                      photon-counting detector (PCD). While the EID provides a
                      pixel size of 0.6 mm in the centre of rotation, the PCD
                      provides a pixel size of 0.25 mm. Additionally, it provides
                      a quantification of photon energies by sorting them into up
                      to four distinct energy bins. This acquisition of
                      multi-energy data allows for a multitude of applications,
                      e.g. pseudo-monochromatic imaging. In particular, we examine
                      the relation between spatial resolution, image noise and
                      administered radiation dose for a multitude of use-cases.
                      These cases include ultra-high resolution and multi-energy
                      acquisitions of mice administered with a prototype
                      bismuth-based contrast agent (nanoPET Pharma, Berlin,
                      Germany) as well as larger animals and actual patients. The
                      clinical EID provides a spatial resolution of about 9 lp/cm
                      (modulation transfer function at $10\%,$ $MTF10\%)$ while
                      UHR allows for the acquisition of images with up to 16 lp/cm
                      allowing for the visualization of all relevant anatomical
                      structures in preclinical and clinical specimen. The
                      spectral capabilities of the system enable a variety of
                      applications previously not available in preclinical
                      research such as pseudo-monochromatic images. Clinical
                      ultra-high resolution photon-counting CT has the potential
                      to unify preclinical and clinical research on a single
                      system enabling versatile imaging of specimens and
                      individuals ranging from mice to man.},
      keywords     = {Micro-CT (Other) / Photon-Counting CT (Other) /
                      Translational Medicine (Other)},
      cin          = {E010 / E025 / E040},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)E025-20160331 /
                      I:(DE-He78)E040-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35868888},
      doi          = {10.1016/j.zemedi.2022.06.002},
      url          = {https://inrepo02.dkfz.de/record/180773},
}