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@ARTICLE{Doege:180781,
      author       = {D. Doege$^*$ and M. Thong$^*$ and L. Koch-Gallenkamp$^*$
                      and H. Bertram and A. Eberle and B. Holleczek and A.
                      Nennecke and R. Pritzkuleit and A. Waldmann and S. R.
                      Zeissig and H. Brenner$^*$ and V. Arndt$^*$},
      title        = {{C}linical and sociodemographic determinants of
                      disease-specific health-related quality of life in long-term
                      breast cancer survivors.},
      journal      = {Journal of cancer research and clinical oncology},
      volume       = {148},
      number       = {12},
      issn         = {0171-5216},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2022-01546},
      pages        = {3461-3473},
      year         = {2022},
      note         = {#EA:C071#LA:C071# / 2022 Dec;148(12):3461-3473},
      abstract     = {It is important to monitor disease-specific health-related
                      quality of life (HRQoL) in breast cancer (BC) survivors to
                      identify potential unmet supportive care needs. However,
                      previous studies were characterized by small samples of
                      mostly short-term survivors and were limited to certain age
                      ranges, stages and/or treatments.We used data from 3045
                      long-term BC survivors (5-15 years post-diagnosis) recruited
                      in a German multi-regional population-based study. We
                      assessed disease-specific HRQoL with the EORTC QLQ-BR23,
                      scoring from 0 to 100. Differences in functioning and
                      symptoms according to age at survey, self-reported
                      treatments, stage, and disease status (disease-free vs.
                      active disease) were assessed with multiple regression.
                      Active disease was defined as any self-report of recurrence,
                      metastasis or second primary cancer after the index
                      cancer.Older BC survivors reported a higher body image and a
                      better future perspective, but lower sexual functioning.
                      Survivors aged 30-49 years who had breast-conserving therapy
                      or mastectomy with breast reconstruction reported a better
                      body image compared to those who had mastectomy only. We
                      also found differences in symptoms according to treatments
                      in some age groups. Stage at diagnosis was not associated
                      with HRQoL overall and in most age subgroups. Disease-free
                      BC survivors aged 30-79 years reported a better future
                      perspective and less systemic therapy side effects than
                      those with active disease.Several treatment-associated
                      symptoms and functioning detriments were found 5-15 years
                      after diagnosis. The results emphasize the need of a
                      comprehensive, individualized survivorship care, recognizing
                      differential needs of long-term BC survivors according to
                      age, treatment modalities, and disease status.},
      keywords     = {Adverse effects (Other) / Body image (Other) / Breast
                      cancer survivors (Other) / Disease-specific issues (Other) /
                      Hair loss (Other) / Quality of life (Other) / Sexuality
                      (Other)},
      cin          = {C071 / C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C071-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35879433},
      doi          = {10.1007/s00432-022-04204-w},
      url          = {https://inrepo02.dkfz.de/record/180781},
}