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@ARTICLE{Lindsay:180837,
      author       = {H. B. Lindsay and M. Massimino and S. Avula and S. Stivaros
                      and R. Grundy and K. Metrock and A. Bhatia and A.
                      Fernández-Teijeiro and L. Chiapparini and J. Bennett and K.
                      Wright and L. M. Hoffman and A. Smith and K. Pajtler$^*$ and
                      T. Y. Poussaint and K. E. Warren and N. K. Foreman and D. M.
                      Mirsky},
      title        = {{R}esponse assessment in paediatric intracranial
                      ependymoma: recommendations from the {R}esponse {A}ssessment
                      in {P}ediatric {N}euro-{O}ncology ({RAPNO}) working group.},
      journal      = {The lancet / Oncology},
      volume       = {23},
      number       = {8},
      issn         = {1470-2045},
      address      = {London},
      publisher    = {The Lancet Publ. Group},
      reportid     = {DKFZ-2022-01586},
      pages        = {e393-e401},
      year         = {2022},
      note         = {2022 Aug;23(8):e393-e401},
      abstract     = {Response criteria for paediatric intracranial ependymoma
                      vary historically and across different international
                      cooperative groups. The Response Assessment in the Pediatric
                      Neuro-Oncology (RAPNO) working group, consisting of an
                      international panel of paediatric and adult
                      neuro-oncologists, neuro-radiologists, radiation
                      oncologists, and neurosurgeons, was established to address
                      both the issues and the unique challenges in assessing the
                      response in children with CNS tumours. We established a
                      subcommittee to develop response assessment criteria for
                      paediatric ependymoma. Current practice and literature were
                      reviewed to identify major challenges in assessing the
                      response of paediatric ependymoma to clinical trial therapy.
                      For areas in which data were scarce or unavailable,
                      consensus was reached through an iterative process. RAPNO
                      response assessment recommendations include assessing
                      disease response on the basis of changes in tumour volume,
                      and using event-free survival as a study endpoint for
                      patients entering clinical trials without bulky disease. Our
                      recommendations for response assessment include the use of
                      brain and spine MRI, cerebral spinal fluid cytology,
                      neurological examination, and steroid use. Baseline
                      postoperative imaging to assess for residual tumour should
                      be obtained 24-48 h after surgery. Our consensus
                      recommendations and response definitions should be
                      prospectively validated in clinical trials.},
      subtyp        = {Review Article},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35901835},
      doi          = {10.1016/S1470-2045(22)00222-4},
      url          = {https://inrepo02.dkfz.de/record/180837},
}