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@ARTICLE{Dimou:180841,
      author       = {N. Dimou and W. Omiyale and C. Biessy and V. Viallon and R.
                      Kaaks$^*$ and T. A. O'Mara and E. K. Aglago and E. Ardanaz
                      and M. M. Bergmann and N. P. Bondonno and T. Braaten and S.
                      M. Colorado-Yohar and M. Crous-Bou and C. C. Dahm and R.
                      Turzanski-Fortner$^*$ and I. T. Gram and S. Harlid and A. K.
                      Heath and A. Idahl and M. Kvaskoff and T. H. Nøst and K.
                      Overvad and D. Palli and A. Perez-Cornago and C. Sacerdote
                      and M.-J. Sánchez and M. B. Schulze and G. Severi and V.
                      Simeon and G. Tagliabue and A. Tjønneland and T. Truong and
                      R. Tumino and M. Johansson and E. Weiderpass and N. Murphy
                      and M. J. Gunter and B. Lacey and N. E. Allen and L. Dossus},
      title        = {{C}igarette {S}moking and {E}ndometrial {C}ancer {R}isk:
                      {O}bservational and {M}endelian {R}andomization {A}nalyses.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {31},
      number       = {9},
      issn         = {1055-9965},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2022-01590},
      pages        = {1839-1848},
      year         = {2022},
      note         = {2022 Sep 2;31(9):1839-1848},
      abstract     = {Current epidemiologic evidence indicates that smoking is
                      associated with a lower endometrial cancer risk. However, it
                      is unknown if this association is causal or confounded. To
                      further elucidate the role of smoking in endometrial cancer
                      risk, we conducted complementary observational and Mendelian
                      randomization (MR) analyses.The observational analyses
                      included 286,415 participants enrolled in the European
                      Prospective Investigation into Cancer and Nutrition and
                      179,271 participants in the UK Biobank, and multivariable
                      Cox proportional hazards models were used. In two-sample MR
                      analyses, genetic variants robustly associated with lifetime
                      amount of smoking (n = 126 variants) and ever having smoked
                      regularly (n = 112 variants) were selected and their
                      association with endometrial cancer risk (12,906
                      cancer/108,979 controls from the Endometrial Cancer
                      Association Consortium) was examined.In the observational
                      analysis, lifetime amount of smoking and ever having smoked
                      regularly were associated with a lower endometrial cancer
                      risk. In the MR analysis accounting for body mass index, a
                      genetic predisposition to a higher lifetime amount of
                      smoking was not associated with endometrial cancer risk (OR
                      per 1-SD increment: 1.15; $95\%$ confidence interval:
                      0.91-1.44). Genetic predisposition to ever having smoked
                      regularly was not associated with risk of endometrial
                      cancer.Smoking was inversely associated with endometrial
                      cancer in the observational analyses, although unsupported
                      by the MR. Additional studies are required to better
                      understand the possible confounders and mechanisms
                      underlying the observed associations between smoking and
                      endometrial cancer.The results from this analysis indicate
                      that smoking is unlikely to be causally linked with
                      endometrial cancer risk.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35900194},
      doi          = {10.1158/1055-9965.EPI-21-1176},
      url          = {https://inrepo02.dkfz.de/record/180841},
}