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@ARTICLE{Rud:180916,
      author       = {R. Rudà and D. Capper$^*$ and A. D. Waldman and J. Pallud
                      and G. Minniti and T. J. Kaley and E. Bouffet and G.
                      Tabatabai$^*$ and E. Aronica and A. S. Jakola and S.
                      Pfister$^*$ and D. Schiff and A. B. Lassman and D. A.
                      Solomon and R. Soffietti and M. Weller and M. Preusser and
                      A. Idbaih and P. Y. Wen and M. J. van den Bent},
      title        = {{E}ano-{E}uracan-{S}no {G}uidelines on {C}ircumscribed
                      {A}strocytic {GLIOMAS}, {G}lioneuronal and {N}euronaltumors},
      journal      = {Neuro-Oncology},
      volume       = {24},
      number       = {12},
      issn         = {1522-8517},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2022-01641},
      pages        = {2015-2034},
      year         = {2022},
      note         = {2022 Dec 1;24(12):2015-2034},
      abstract     = {In the new WHO 2021 Classification of CNS Tumors the
                      chapter “Circumscribed astrocytic gliomas, glioneuronal
                      and neuronal tumors” encompasses several different rare
                      tumor entities, which occur more frequently in children,
                      adolescents and young adults. The Task Force has reviewed
                      the evidence of diagnostic and therapeutic interventions,
                      which is low particularly for adult patients, and draw
                      recommendations accordingly. Tumor diagnosis, based on WHO
                      2021, is primarily performed using conventional histological
                      techniques; however, molecular workup is important for
                      differential diagnosis, in particular DNA methylation
                      profiling for the definitive classification of
                      histologically unresolved cases. Molecular factors are
                      increasingly of prognostic and predictive importance. MRI
                      finding are non specific, but for some tumors are
                      characteristic and suggestive. Gross total resection, when
                      feasible, is the most important treatment in terms of
                      prolonging survival and achieving long-term seizure control.
                      Conformal radiotherapy should be considered in grade 3 and
                      incompletely resected grade 2 tumors. In recurrent tumors
                      reoperation and radiotherapy, including stereotactic
                      radiotherapy, can be useful. Targeted therapies may be used
                      in selected patients: BRAF and MEK inhibitors in pilocytic
                      astrocytomas, pleomorphic xanthoastrocytomas, and
                      gangliogliomas when BRAF altered, and mTOR inhibitor
                      everolimus in subependymal giant cells astrocytomas
                      .Sequencing to identify molecular targets is advocated for
                      diagnostic clarification and to direct potential targeted
                      therapies.},
      subtyp        = {Review Article},
      cin          = {BE01 / TU01 / B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331 / I:(DE-He78)TU01-20160331 /
                      I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35908833},
      doi          = {10.1093/neuonc/noac188},
      url          = {https://inrepo02.dkfz.de/record/180916},
}