TY  - JOUR
AU  - Byun, Jinyoung
AU  - Han, Younghun
AU  - Li, Yafang
AU  - Xia, Jun
AU  - Long, Erping
AU  - Choi, Jiyeon
AU  - Xiao, Xiangjun
AU  - Zhu, Meng
AU  - Zhou, Wen
AU  - Sun, Ryan
AU  - Bossé, Yohan
AU  - Song, Zhuoyi
AU  - Schwartz, Ann
AU  - Lusk, Christine
AU  - Rafnar, Thorunn
AU  - Stefansson, Kari
AU  - Zhang, Tongwu
AU  - Zhao, Wei
AU  - Pettit, Rowland W
AU  - Liu, Yanhong
AU  - Li, Xihao
AU  - Zhou, Hufeng
AU  - Walsh, Kyle M
AU  - Gorlov, Ivan
AU  - Gorlova, Olga
AU  - Zhu, Dakai
AU  - Rosenberg, Susan M
AU  - Pinney, Susan
AU  - Bailey-Wilson, Joan E
AU  - Mandal, Diptasri
AU  - de Andrade, Mariza
AU  - Gaba, Colette
AU  - Willey, James C
AU  - You, Ming
AU  - Anderson, Marshall
AU  - Wiencke, John K
AU  - Albanes, Demetrius
AU  - Lam, Stephan
AU  - Tardon, Adonina
AU  - Chen, Chu
AU  - Goodman, Gary
AU  - Bojeson, Stig
AU  - Brenner, Hermann
AU  - Landi, Maria Teresa
AU  - Chanock, Stephen J
AU  - Johansson, Mattias
AU  - Muley, Thomas
AU  - Risch, Angela
AU  - Wichmann, H-Erich
AU  - Bickeböller, Heike
AU  - Christiani, David C
AU  - Rennert, Gad
AU  - Arnold, Susanne
AU  - Field, John K
AU  - Shete, Sanjay
AU  - Le Marchand, Loic
AU  - Melander, Olle
AU  - Brunnstrom, Hans
AU  - Liu, Geoffrey
AU  - Andrew, Angeline S
AU  - Kiemeney, Lambertus A
AU  - Shen, Hongbing
AU  - Zienolddiny, Shanbeh
AU  - Grankvist, Kjell
AU  - Johansson, Mikael
AU  - Caporaso, Neil
AU  - Cox, Angela
AU  - Hong, Yun-Chul
AU  - Yuan, Jian-Min
AU  - Lazarus, Philip
AU  - Schabath, Matthew B
AU  - Aldrich, Melinda C
AU  - Patel, Alpa
AU  - Lan, Qing
AU  - Rothman, Nathaniel
AU  - Taylor, Fiona
AU  - Kachuri, Linda
AU  - Witte, John S
AU  - Sakoda, Lori C
AU  - Spitz, Margaret
AU  - Brennan, Paul
AU  - Lin, Xihong
AU  - McKay, James
AU  - Hung, Rayjean J
AU  - Amos, Christopher I
TI  - Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.
JO  - Nature genetics
VL  - 54
IS  - 8
SN  - 1061-4036
CY  - London
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2022-01715
SP  - 1167-1177
PY  - 2022
N1  - 2022 Aug;54(8):1167-1177
AB  - To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to populations, but even common-variant associations influencing smoking behavior, such as those with CHRNA5 and CYP2A6, showed population specificity. Fine-mapping and expression quantitative trait locus colocalization nominated several candidate variants and susceptibility genes such as IRF4 and FUBP1. DNA damage assays of prioritized genes in lung fibroblasts indicated that a subset of these genes, including the pleiotropic gene IRF4, potentially exert effects by promoting endogenous DNA damage.
LB  - PUB:(DE-HGF)16
C6  - pmid:35915169
DO  - DOI:10.1038/s41588-022-01115-x
UR  - https://inrepo02.dkfz.de/record/180991
ER  -