%0 Journal Article
%A Vogel-Claussen, Jens
%A Lasch, Florian
%A Bollmann, Benjamin-Alexander
%A May, Katharina
%A Kuhlmann, Alexander
%A Schmid-Bindert, Gerald
%A Kaaks, Rudolf
%A Barkhausen, Jörg
%A Bohnet, Sabine
%A Reck, Martin
%T Design and Rationale of the HANSE Study: A Holistic German Lung Cancer Screening Trial Using Low-Dose Computed Tomography [Design und Rationale der HANSE-Studie: Eine ganzheitliche deutsche Lungenkrebs-Früherkennungs-Studie unter Verwendung von Niedrigdosis-Computertomografie].
%J RöFo
%V 194
%N 12
%@ 0015-8151
%C Stuttgart [u.a.]
%I Thieme
%M DKFZ-2022-01724
%P 1333-1345
%D 2022
%Z 2022 Dec;194(12):1333-1345
%X Despite the high prevalence and mortality of lung cancer and proven effectiveness of low-dose computed tomography (LDCT) to reduce mortality, Germany still lacks a national screening program. The German Institute for Quality and Efficiency in Health Care (IQWiG) and the Federal Office for Radiation Protection (BfS) both published positive scientific evaluations recommending a quality-controlled national screening program. IQWiG underlined the importance of a clear risk definition, integrated smoking cessation programs, and quality assurance, highlighting the necessity of procedural optimization. In the HANSE study, former and current smokers aged 55-79 years are assessed for their lung cancer risk by the NELSON and PLCOM2012 risk scores. 5000 high-risk participants, defined as PLCOM2012 6-year risk ≥ 1.58 
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35917826
%R 10.1055/a-1853-8291
%U https://inrepo02.dkfz.de/record/181016