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000181074 0247_ $$2doi$$a10.1016/j.ejca.2022.06.011
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000181074 041__ $$aEnglish
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000181074 1001_ $$aGrootes, Isabelle$$b0
000181074 245__ $$aIncorporating progesterone receptor expression into the PREDICT breast prognostic model.
000181074 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2022
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000181074 520__ $$aPredict Breast (www.predict.nhs.uk) is an online prognostication and treatment benefit tool for early invasive breast cancer. The aim of this study was to incorporate the prognostic effect of progesterone receptor (PR) status into a new version of PREDICT and to compare its performance to the current version (2.2).The prognostic effect of PR status was based on the analysis of data from 45,088 European patients with breast cancer from 49 studies in the Breast Cancer Association Consortium. Cox proportional hazard models were used to estimate the hazard ratio for PR status. Data from a New Zealand study of 11,365 patients with early invasive breast cancer were used for external validation. Model calibration and discrimination were used to test the model performance.Having a PR-positive tumour was associated with a 23% and 28% lower risk of dying from breast cancer for women with oestrogen receptor (ER)-negative and ER-positive breast cancer, respectively. The area under the ROC curve increased with the addition of PR status from 0.807 to 0.809 for patients with ER-negative tumours (p = 0.023) and from 0.898 to 0.902 for patients with ER-positive tumours (p = 2.3 × 10-6) in the New Zealand cohort. Model calibration was modest with 940 observed deaths compared to 1151 predicted.The inclusion of the prognostic effect of PR status to PREDICT Breast has led to an improvement of model performance and more accurate absolute treatment benefit predictions for individual patients. Further studies should determine whether the baseline hazard function requires recalibration.
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000181074 650_7 $$2Other$$aPREDICT Breast
000181074 650_7 $$2Other$$aProgesterone receptor
000181074 650_7 $$2Other$$aPrognosis
000181074 650_7 $$2Other$$abreast cancer
000181074 7001_ $$aKeeman, Renske$$b1
000181074 7001_ $$aBlows, Fiona M$$b2
000181074 7001_ $$aMilne, Roger L$$b3
000181074 7001_ $$aGiles, Graham G$$b4
000181074 7001_ $$aSwerdlow, Anthony J$$b5
000181074 7001_ $$aFasching, Peter A$$b6
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000181074 7001_ $$aBeckmann, Matthias W$$b10
000181074 7001_ $$aBlomqvist, Carl$$b11
000181074 7001_ $$aBojesen, Stig E$$b12
000181074 7001_ $$aBolla, Manjeet K$$b13
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000181074 7001_ $$aCamp, Nicola J$$b17
000181074 7001_ $$aCastelao, Jose E$$b18
000181074 7001_ $$aChoi, Ji-Yeob$$b19
000181074 7001_ $$aClarke, Christine L$$b20
000181074 7001_ $$aCouch, Fergus J$$b21
000181074 7001_ $$aCox, Angela$$b22
000181074 7001_ $$aCross, Simon S$$b23
000181074 7001_ $$aCzene, Kamila$$b24
000181074 7001_ $$aDevilee, Peter$$b25
000181074 7001_ $$aDörk, Thilo$$b26
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000181074 7001_ $$aDwek, Miriam$$b28
000181074 7001_ $$aEaston, Douglas F$$b29
000181074 7001_ $$aEccles, Diana M$$b30
000181074 7001_ $$aEriksson, Mikael$$b31
000181074 7001_ $$aErnst, Kristina$$b32
000181074 7001_ $$aEvans, D Gareth$$b33
000181074 7001_ $$aFigueroa, Jonine D$$b34
000181074 7001_ $$aFink, Visnja$$b35
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000181074 7001_ $$aHou, Ming-Feng$$b50
000181074 7001_ $$aHowell, Sacha J$$b51
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000181074 7001_ $$aIto, Hidemi$$b54
000181074 7001_ $$aJakubowska, Anna$$b55
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000181074 7001_ $$aKang, Daehee$$b59
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000181074 7001_ $$aLambrechts, Diether$$b62
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000181074 7001_ $$aLubiński, Jan$$b64
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000181074 7001_ $$aMatsuo, Keitaro$$b67
000181074 7001_ $$aTaib, Nur Aishah Mohd$$b68
000181074 7001_ $$aMulligan, Anna Marie$$b69
000181074 7001_ $$aNevanlinna, Heli$$b70
000181074 7001_ $$aNewman, William G$$b71
000181074 7001_ $$aOffit, Kenneth$$b72
000181074 7001_ $$aOsorio, Ana$$b73
000181074 7001_ $$aPark, Sue K$$b74
000181074 7001_ $$aPark-Simon, Tjoung-Won$$b75
000181074 7001_ $$aPatel, Alpa V$$b76
000181074 7001_ $$aPresneau, Nadege$$b77
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000181074 7001_ $$aSaloustros, Emmanouil$$b83
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000181074 7001_ $$aSchneeweiss, Andreas$$b85
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000181074 7001_ $$aSchoemaker, Minouk J$$b87
000181074 7001_ $$aShen, Chen-Yang$$b88
000181074 7001_ $$aShibli, Rana$$b89
000181074 7001_ $$aSinn, Peter$$b90
000181074 7001_ $$aTapper, William J$$b91
000181074 7001_ $$aTawfiq, Essa$$b92
000181074 7001_ $$aTeo, Soo Hwang$$b93
000181074 7001_ $$aTeras, Lauren R$$b94
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000181074 7001_ $$aVachon, Celine M$$b96
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