TY  - JOUR
AU  - Jaeschke, Lina
AU  - Becher, Matthias
AU  - Velásquez, Ilais Moreno
AU  - Ahrens, Wolfgang
AU  - Bächle, Christina
AU  - Baurecht, Hansjörg
AU  - Fricke, Julia
AU  - Greiser, Karin Halina
AU  - Günther, Kathrin
AU  - Heier, Margit
AU  - Karch, André
AU  - Kluttig, Alexander
AU  - Krist, Lilian
AU  - Leitzmann, Michael
AU  - Michels, Karin
AU  - Mikolajczyk, Rafael
AU  - Peters, Annette
AU  - Schipf, Sabine
AU  - Völzke, Henry
AU  - Pischon, Tobias
AU  - Becher, Heiko
TI  - The bias from heaping on risk estimation: Effect of age at diagnosis of hypertension on risk of subsequent cardiovascular comorbidities.
JO  - Annals of epidemiology
VL  - 74
SN  - 1047-2797
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2022-01765
SP  - 84-96
PY  - 2022
N1  - 2022 Aug 5;74:84-96
AB  - To investigate (1) the bias in effect estimation due to heaping, (2) the association between age at hypertension diagnosis and risk of cardiovascular comorbidities, and (3) the influence of heaping on risk estimates.We performed a simulation study with various scenarios, binary outcome, and normal or lognormal distributed covariables. We calculated mean logistic coefficients under the original and heaped data and their relative deviation. The association of age at hypertension diagnosis and risk of ≥1 cardiovascular comorbidity was investigated using logistic regression among 50,858 participants in the NAKO Gesundheitsstudie (German National Cohort) who reported such diagnosis. We assessed the proportion of heaped observations and to what extent heaping may have influenced risk estimates.Based on the simulation study and assuming 50
KW  - cardiovascular comorbidities (Other)
KW  - digit preference (Other)
KW  - effect estimates (Other)
KW  - epidemiologic study (Other)
KW  - heaping (Other)
KW  - hypertension (Other)
KW  - simulation study (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35940393
DO  - DOI:10.1016/j.annepidem.2022.07.012
UR  - https://inrepo02.dkfz.de/record/181081
ER  -