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@ARTICLE{Konigorski:181109,
      author       = {S. Konigorski and J. Janke and G. Patone and M. M. Bergmann
                      and C. Lippert and N. Hübner and R. Kaaks$^*$ and H. Boeing
                      and T. Pischon},
      title        = {{I}dentification of novel genes whose expression in adipose
                      tissue affects body fat mass and distribution: an
                      {RNA}-{S}eq and {M}endelian {R}andomization study.},
      journal      = {European journal of human genetics},
      volume       = {32},
      number       = {9},
      issn         = {1018-4813},
      address      = {Basingstoke},
      publisher    = {Stockton Press},
      reportid     = {DKFZ-2022-01778},
      pages        = {1127-1135},
      year         = {2024},
      note         = {2024 Sep;32(9):1127-1135},
      abstract     = {Many studies have shown that abdominal adiposity is more
                      strongly related to health risks than peripheral adiposity.
                      However, the underlying pathways are still poorly
                      understood. In this cross-sectional study using data from
                      RNA-sequencing experiments and whole-body MRI scans of 200
                      participants in the EPIC-Potsdam cohort, our aim was to
                      identify novel genes whose gene expression in subcutaneous
                      adipose tissue has an effect on body fat mass (BFM) and body
                      fat distribution (BFD). The analysis identified 625 genes
                      associated with adiposity, of which 531 encode a known
                      protein and 487 are novel candidate genes for obesity.
                      Enrichment analyses indicated that BFM-associated genes were
                      characterized by their higher than expected involvement in
                      cellular, regulatory and immune system processes, and
                      BFD-associated genes by their involvement in cellular,
                      metabolic, and regulatory processes. Mendelian Randomization
                      analyses suggested that the gene expression of 69 genes was
                      causally related to BFM and BFD. Six genes were replicated
                      in UK Biobank. In this study, we identified novel genes for
                      BFM and BFD that are BFM- and BFD-specific, involved in
                      different molecular processes, and whose up-/downregulated
                      gene expression may causally contribute to obesity.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35953519},
      doi          = {10.1038/s41431-022-01161-3},
      url          = {https://inrepo02.dkfz.de/record/181109},
}