%0 Journal Article
%A Raut, Janhavi
%A Bhardwaj, Megha
%A Niedermaier, Tobias
%A Miah, Kaya
%A Schrotz-King, Petra
%A Brenner, Hermann
%T Assessment of a Serum Microrna Risk Score for Colorectal Cancer among Participants of Screening Colonoscopy at Various Stages of Colorectal Carcinogenesis.
%J Cells
%V 11
%N 15
%@ 2073-4409
%C Basel
%I MDPI
%M DKFZ-2022-01786
%P 2462
%D 2022
%Z #EA:C070#EA:C120#LA:C070#LA:C120#
%X We recently derived and validated a serum-based microRNA risk score (miR-score) which predicted colorectal cancer (CRC) occurrence with very high accuracy within 14 years of follow-up in a large population-based cohort. Here, we aimed to assess and compare the distribution of the miR-score among participants of screening colonoscopy at various stages of colorectal carcinogenesis. MicroRNAs (miRNAs) were profiled by quantitative-real-time-polymerase-chain-reaction in the serum samples of screening colonoscopy participants with CRC (n = 52), advanced colorectal adenoma (AA, n = 100), non-advanced colorectal adenoma (NAA, n = 88), and participants free of colorectal neoplasms (n = 173). The mean values of the miR-score were compared between groups by the Mann-Whitney U test. The associations of the miR-score with risk for colorectal neoplasms were evaluated using logistic regression analyses. MicroRNA risk scores were significantly higher among participants with AA than among those with NAA (p = 0.027) and those with CRC (p = 0.014), whereas no statistically significant difference was seen between those with NAA and those with no colorectal neoplasms (p = 0.127). When comparing adjacent groups, miR-scores were inversely associated with CRC versus AA and positively associated with AA versus NAA [odds ratio (OR), 0.37 (95
%K blood-based (Other)
%K colorectal cancer (Other)
%K miRNA (Other)
%K risk stratification (Other)
%K risk-adapted screening (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35954306
%R 10.3390/cells11152462
%U https://inrepo02.dkfz.de/record/181117