TY  - JOUR
AU  - Raut, Janhavi
AU  - Bhardwaj, Megha
AU  - Niedermaier, Tobias
AU  - Miah, Kaya
AU  - Schrotz-King, Petra
AU  - Brenner, Hermann
TI  - Assessment of a Serum Microrna Risk Score for Colorectal Cancer among Participants of Screening Colonoscopy at Various Stages of Colorectal Carcinogenesis.
JO  - Cells
VL  - 11
IS  - 15
SN  - 2073-4409
CY  - Basel
PB  - MDPI
M1  - DKFZ-2022-01786
SP  - 2462
PY  - 2022
N1  - #EA:C070#EA:C120#LA:C070#LA:C120#
AB  - We recently derived and validated a serum-based microRNA risk score (miR-score) which predicted colorectal cancer (CRC) occurrence with very high accuracy within 14 years of follow-up in a large population-based cohort. Here, we aimed to assess and compare the distribution of the miR-score among participants of screening colonoscopy at various stages of colorectal carcinogenesis. MicroRNAs (miRNAs) were profiled by quantitative-real-time-polymerase-chain-reaction in the serum samples of screening colonoscopy participants with CRC (n = 52), advanced colorectal adenoma (AA, n = 100), non-advanced colorectal adenoma (NAA, n = 88), and participants free of colorectal neoplasms (n = 173). The mean values of the miR-score were compared between groups by the Mann-Whitney U test. The associations of the miR-score with risk for colorectal neoplasms were evaluated using logistic regression analyses. MicroRNA risk scores were significantly higher among participants with AA than among those with NAA (p = 0.027) and those with CRC (p = 0.014), whereas no statistically significant difference was seen between those with NAA and those with no colorectal neoplasms (p = 0.127). When comparing adjacent groups, miR-scores were inversely associated with CRC versus AA and positively associated with AA versus NAA [odds ratio (OR), 0.37 (95
KW  - blood-based (Other)
KW  - colorectal cancer (Other)
KW  - miRNA (Other)
KW  - risk stratification (Other)
KW  - risk-adapted screening (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35954306
DO  - DOI:10.3390/cells11152462
UR  - https://inrepo02.dkfz.de/record/181117
ER  -