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@ARTICLE{Raut:181117,
      author       = {J. Raut$^*$ and M. Bhardwaj$^*$ and T. Niedermaier$^*$ and
                      K. Miah$^*$ and P. Schrotz-King$^*$ and H. Brenner$^*$},
      title        = {{A}ssessment of a {S}erum {M}icrorna {R}isk {S}core for
                      {C}olorectal {C}ancer among {P}articipants of {S}creening
                      {C}olonoscopy at {V}arious {S}tages of {C}olorectal
                      {C}arcinogenesis.},
      journal      = {Cells},
      volume       = {11},
      number       = {15},
      issn         = {2073-4409},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2022-01786},
      pages        = {2462},
      year         = {2022},
      note         = {#EA:C070#EA:C120#LA:C070#LA:C120#},
      abstract     = {We recently derived and validated a serum-based microRNA
                      risk score (miR-score) which predicted colorectal cancer
                      (CRC) occurrence with very high accuracy within 14 years of
                      follow-up in a large population-based cohort. Here, we aimed
                      to assess and compare the distribution of the miR-score
                      among participants of screening colonoscopy at various
                      stages of colorectal carcinogenesis. MicroRNAs (miRNAs) were
                      profiled by quantitative-real-time-polymerase-chain-reaction
                      in the serum samples of screening colonoscopy participants
                      with CRC (n = 52), advanced colorectal adenoma (AA, n =
                      100), non-advanced colorectal adenoma (NAA, n = 88), and
                      participants free of colorectal neoplasms (n = 173). The
                      mean values of the miR-score were compared between groups by
                      the Mann-Whitney U test. The associations of the miR-score
                      with risk for colorectal neoplasms were evaluated using
                      logistic regression analyses. MicroRNA risk scores were
                      significantly higher among participants with AA than among
                      those with NAA (p = 0.027) and those with CRC (p = 0.014),
                      whereas no statistically significant difference was seen
                      between those with NAA and those with no colorectal
                      neoplasms (p = 0.127). When comparing adjacent groups,
                      miR-scores were inversely associated with CRC versus AA and
                      positively associated with AA versus NAA [odds ratio (OR),
                      0.37 $(95\%$ confidence interval (CI), 0.16-0.86) and OR,
                      2.22 $(95\%$ CI, 1.06-4.64) for the top versus bottom
                      tertiles, respectively]. Our results are consistent with the
                      hypothesis that a high miR-score may be indicative of an
                      increased CRC risk by an increased tendency of progression
                      from non-advanced to advanced colorectal neoplasms, along
                      with a change of the miR-patterns after CRC manifestation.},
      keywords     = {blood-based (Other) / colorectal cancer (Other) / miRNA
                      (Other) / risk stratification (Other) / risk-adapted
                      screening (Other)},
      cin          = {C070 / C120 / C060 / HD01},
      ddc          = {570},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)C060-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35954306},
      doi          = {10.3390/cells11152462},
      url          = {https://inrepo02.dkfz.de/record/181117},
}