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@ARTICLE{Struckmeier:181140,
      author       = {A.-K. Struckmeier and A. Radermacher and M. Fehrenz and T.
                      Bellin and D. Alansary and P. Wartenberg and U. Boehm and M.
                      Wagner and A. Scheller and J. Hess$^*$ and J. Moratin and C.
                      Freudlsperger and J. Hoffmann and L. Thurner and K. Roemer
                      and K. Freier and D. Horn},
      title        = {{IDO}1 is highly expressed in macrophages of patients in
                      advanced tumour stages of oral squamous cell carcinoma.},
      journal      = {Journal of cancer research and clinical oncology},
      volume       = {149},
      number       = {7},
      issn         = {0171-5216},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DKFZ-2022-01793},
      pages        = {3623-3635},
      year         = {2023},
      note         = {2023 Jul;149(7):3623-3635},
      abstract     = {Strategies for Indolamine-2,3-dioxygenase 1 (IDO1)
                      inhibition in cancer immunotherapy once produced encouraging
                      results, but failed in clinical trials. Recent evidence
                      indicates that immune cells in the tumour microenvironment,
                      especially macrophages, contribute to immune dysregulation
                      and therefore might play a critical role in drug
                      resistance.In this study, we investigated the significance
                      of IDO1 expressing immune cells in primary tumours and
                      corresponding lymph node metastases (LNMs) in oral squamous
                      cell carcinoma (OSCC) by immunohistochemistry. The link
                      between IDO1 and macrophages was investigated by flow
                      cytometry in tumour tissue, healthy adjacent tissue and
                      peripheral blood mononuclear cells (PBMCs). IDO1 activity
                      (measured as Kynurenine/Tryptophan ratio) was assessed by
                      ELISAs.High IDO1 expression in tumour-infiltrating immune
                      cells was significantly correlated with advanced stages
                      [Spearman's rank correlation (SRC), p = 0.027] and reduced
                      progression-free survival (multivariate Cox regression, p =
                      0.034). IDO1 was significantly higher expressed in PBMCs of
                      patients in advanced stages than in healthy controls (ANOVA,
                      p < 0.05) and IDO1+ macrophages were more abundant in
                      intratumoural areas than peritumoural (t test, p < 0.001).
                      IDO1 expression in PBMCs was significantly correlated with
                      IDO1 activity in serum (SRC, p < 0.05). IDO1 activity was
                      significantly higher in patients with LNMs (t test, p <
                      0.01).All in all, IDO1 expressing immune cells, especially
                      macrophages, are more abundant in advanced stages of OSCC
                      and are associated with reduced progression-free survival.
                      Further investigations are needed to explore their role in
                      local and systemic immune response. The IDO1 activity might
                      be a suitable biomarker of metastasis in OSCC patients.},
      keywords     = {IDO (Other) / Immunotherapy (Other) / Macrophage (Other) /
                      Oral squamous cell carcinoma (OSCC) (Other) / Tumour
                      microenvironment (Other)},
      cin          = {E221},
      ddc          = {610},
      cid          = {I:(DE-He78)E221-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35963900},
      doi          = {10.1007/s00432-022-04277-7},
      url          = {https://inrepo02.dkfz.de/record/181140},
}