%0 Journal Article
%A Ambrozkiewicz, Filip
%A Trailin, Andriy
%A Červenková, Lenka
%A Vaclavikova, Radka
%A Hanicinec, Vojtech
%A Allah, Mohammad Al Obeed
%A Palek, Richard
%A Třeška, Vladislav
%A Daum, Ondrej
%A Tonar, Zbyněk
%A Liška, Václav
%A Hemminki, Kari
%T CTNNB1 mutations, TERT polymorphism and CD8+ cell densities in resected hepatocellular carcinoma are associated with longer time to recurrence.
%J BMC cancer
%V 22
%N 1
%@ 1471-2407
%C Heidelberg
%I Springer
%M DKFZ-2022-01799
%P 884
%D 2022
%Z #LA:C020#
%X Hepatocellular carcinoma (HCC) is a fatal disease characterized by early genetic alterations in telomerase reverse transcriptase promoter (TERTp) and β-catenin (CTNNB1) genes and immune cell activation in the tumor microenvironment. As a novel approach, we wanted to assess patient survival influenced by combined presence of mutations and densities of CD8+ cytotoxic T cells.Tissue samples were obtained from 67 HCC patients who had undergone resection. We analysed CD8+ T cells density, TERTp mutations, rs2853669 polymorphism, and CTNNB1 mutations. These variables were evaluated for time to recurrence (TTR) and disease free survival (DFS).TERTp mutations were found in 75.8
%K CD8+ cells (Other)
%K Hepatocellular carcinoma (Other)
%K TERT promoter (Other)
%K rs2853669 (Other)
%K β-Catenin (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35962322
%R 10.1186/s12885-022-09989-0
%U https://inrepo02.dkfz.de/record/181146