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@ARTICLE{Ashekyan:181160,
      author       = {O. Ashekyan and S. Abdallah and A. A. Shoukari and G.
                      Chamandi and H. Choubassy and A. R. S. Itani$^*$ and N.
                      Alwan and R. Nasr},
      title        = {{S}potlight on {E}xosomal {N}on-{C}oding {RNA}s in {B}reast
                      {C}ancer: {A}n {I}n {S}ilico {A}nalysis to {I}dentify
                      {P}otential lnc{RNA}/circ{RNA}-mi{RNA}-{T}arget {A}xis.},
      journal      = {International journal of molecular sciences},
      volume       = {23},
      number       = {15},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DKFZ-2022-01813},
      pages        = {8351},
      year         = {2022},
      abstract     = {Breast cancer (BC) has recently become the most common
                      cancer type worldwide, with metastatic disease being the
                      main reason for disease mortality. This has brought about
                      strategies for early detection, especially the utilization
                      of minimally invasive biomarkers found in various bodily
                      fluids. Exosomes have been proposed as novel extracellular
                      vesicles, readily detectable in bodily fluids, secreted from
                      BC-cells or BC-tumor microenvironment cells, and capable of
                      conferring cellular signals over long distances via various
                      cargo molecules. This cargo is composed of different
                      biomolecules, among which are the novel non-coding genome
                      products, such as microRNAs (miRNAs), long non-coding RNAs
                      (lncRNAs), and the recently discovered circular RNA
                      (circRNA), all of which were found to be implicated in BC
                      pathology. In this review, the diverse roles of the ncRNA
                      cargo of BC-derived exosomes will be discussed, shedding
                      light on their primarily oncogenic and additionally tumor
                      suppressor roles at different levels of BC tumor
                      progression, and drug sensitivity/resistance, along with
                      presenting their diagnostic, prognostic, and predictive
                      biomarker potential. Finally, benefiting from the miRNA
                      sponging mechanism of action of lncRNAs and circRNAs, we
                      established an experimentally validated breast cancer
                      exosomal non-coding RNAs-regulated target gene axis from
                      already published exosomal ncRNAs in BC. The resulting
                      genes, pathways, gene ontology (GO) terms, and Kyoto
                      Encyclopedia of Genes and Genomes (KEGG) analysis could be a
                      starting point to better understand BC and may pave the way
                      for the development of novel diagnostic and prognostic
                      biomarkers and therapeutics.},
      subtyp        = {Review Article},
      keywords     = {biomarkers (Other) / breast cancer (Other) / circular RNAs
                      (Other) / exosomes (Other) / long non-coding RNA (Other) /
                      microRNAs (Other) / non-coding RNA (Other)},
      cin          = {A011},
      ddc          = {540},
      cid          = {I:(DE-He78)A011-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35955480},
      doi          = {10.3390/ijms23158351},
      url          = {https://inrepo02.dkfz.de/record/181160},
}