TY  - JOUR
AU  - Chen, Hongda
AU  - Shi, Jufang
AU  - Lu, Ming
AU  - Li, Yanjie
AU  - Du, Lingbin
AU  - Liao, Xianzhen
AU  - Wei, Donghua
AU  - Dong, Dong
AU  - Gao, Yi
AU  - Zhu, Chen
AU  - Ying, Rongbiao
AU  - Zheng, Weifang
AU  - Yan, Shipeng
AU  - Xiao, Haifan
AU  - Zhang, Juan
AU  - Kong, Yunxin
AU  - Li, Furong
AU  - Zou, Shuangmei
AU  - Liu, Chengcheng
AU  - Wang, Hong
AU  - Zhang, Yuhan
AU  - Lu, Bin
AU  - Luo, Chenyu
AU  - Cai, Jie
AU  - Tian, Jianbo
AU  - Miao, Xiaoping
AU  - Ding, Kefeng
AU  - Brenner, Hermann
AU  - Dai, Min
TI  - Comparison of Colonoscopy, Fecal Immunochemical Test, and Risk-adapted Approach in a Colorectal Cancer Screening Trial (TARGET-C).
JO  - Clinical gastroenterology and hepatology
VL  - 21
IS  - 3
SN  - 1542-3565
CY  - New York, NY
PB  - Elsevier Science
M1  - DKFZ-2022-01818
SP  - 808-818
PY  - 2023
N1  - Volume 21, Issue 3, March 2023, Pages 808-818
AB  - The screening yield and related cost of a risk-adapted screening approach compared with established screening strategies in population-based CRC screening are not clear.We randomly allocated 19,373 participants into one of the three screening arms in a 1:2:2 ratio: (1) one-time colonoscopy (n=3,883); (2) annual fecal immunochemical test (FIT) (n=7,793); (3) annual risk-adapted screening (n=7,697), in which, based on the risk-stratification score, high-risk participants were referred for colonoscopy, and low-risk ones were referred for FIT. Three consecutive screening rounds were conducted for both the FIT and the risk-adapted screening arms. Follow-up to trace the health outcome for all the participants was conducted over the 3-year study period. The detection rate of advanced colorectal neoplasia (CRC and advanced precancerous lesions) was the main outcome. The trial was registered in the Chinese Clinical Trial Registry (number: ChiCTR1800015506).In the colonoscopy, FIT, and risk-adapted screening arms over three screening rounds, the participation rates were 42.4
KW  - colonoscopy (Other)
KW  - colorectal cancer screening (Other)
KW  - fecal immunochemical test (Other)
KW  - personalized screening (Other)
KW  - risk stratification (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35964896
DO  - DOI:10.1016/j.cgh.2022.08.003
UR  - https://inrepo02.dkfz.de/record/181165
ER  -