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@ARTICLE{Li:181188,
      author       = {Li, Constance H. and others},
      title        = {{S}ex differences in oncogenic mutational processes},
      journal      = {Nature Communications},
      volume       = {11},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2022-01841},
      pages        = {4330},
      year         = {2020},
      abstract     = {Sex differences have been observed in multiple facets of
                      cancer epidemiology, treatment and biology, and in most
                      cancers outside the sex organs. Efforts to link these
                      clinical differences to specific molecular features have
                      focused on somatic mutations within the coding regions of
                      the genome. Here we report a pan-cancer analysis of sex
                      differences in whole genomes of 1983 tumours of 28 subtypes
                      as part of the ICGC/TCGA Pan-Cancer Analysis of Whole
                      Genomes (PCAWG) Consortium. We both confirm the results of
                      exome studies, and also uncover previously undescribed sex
                      differences. These include sex-biases in coding and
                      non-coding cancer drivers, mutation prevalence and
                      strikingly, in mutational signatures related to underlying
                      mutational processes. These results underline the
                      pervasiveness of molecular sex differences and strengthen
                      the call for increased consideration of sex in molecular
                      cancer research.},
      cin          = {B370 / B330 / B080 / B060 / B360 / B240 / B260 / B063 /
                      B087 / W190 / HD01 / BE01 / B300},
      ddc          = {500},
      cid          = {I:(DE-He78)B370-20160331 / I:(DE-He78)B330-20160331 /
                      I:(DE-He78)B080-20160331 / I:(DE-He78)B060-20160331 /
                      I:(DE-He78)B360-20160331 / I:(DE-He78)B240-20160331 /
                      I:(DE-He78)B260-20160331 / I:(DE-He78)B063-20160331 /
                      I:(DE-He78)B087-20160331 / I:(DE-He78)W190-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)BE01-20160331 /
                      I:(DE-He78)B300-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32859912},
      doi          = {10.1038/s41467-020-17359-2},
      url          = {https://inrepo02.dkfz.de/record/181188},
}