TY  - JOUR
AU  - Tavakoli, Anoshirwan Andrej
AU  - Hielscher, Thomas
AU  - Badura, Patrick
AU  - Görtz, Magdalena
AU  - Kuder, Tristan Anselm
AU  - Gnirs, Regula
AU  - Schwab, Constantin
AU  - Hohenfellner, Markus
AU  - Schlemmer, Heinz-Peter
AU  - Bonekamp, David
TI  - Contribution of Dynamic Contrast-enhanced and Diffusion MRI to PI-RADS for Detecting Clinically Significant Prostate Cancer.
JO  - Radiology
VL  - 306
IS  - 1
SN  - 0033-8419
CY  - Oak Brook, Ill.
PB  - Soc.
M1  - DKFZ-2022-01879
SP  - 186-199
PY  - 2023
N1  - #EA:E010#LA:E010# / 2023 Jan;306(1):186-199
AB  - Background Prostate Imaging Reporting and Data System (PI-RADS) version 2.0 requires multiparametric MRI of the prostate, including diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) imaging sequences; however, the contribution of DCE imaging remains unclear. Purpose To assess whether DCE imaging in addition to apparent diffusion coefficient (ADC) and normalized T2 values improves PI-RADS version 2.0 for prediction of clinically significant prostate cancer (csPCa). Materials and Methods In this retrospective study, clinically reported PI-RADS lesions in consecutive men who underwent 3-T multiparametric MRI (T2-weighted, DWI, and DCE MRI) from May 2015 to September 2016 were analyzed quantitatively and compared with systematic and targeted MRI-transrectal US fusion biopsy. The normalized T2 signal (nT2), ADC measurement, mean early-phase DCE signal (mDCE), and heuristic DCE parameters were calculated. Logistic regression analysis indicated the most predictive DCE parameters for csPCa (Gleason grade group ≥2). Receiver operating characteristic parameter models were compared using the Obuchowski test. Recursive partitioning analysis determined ADC and mDCE value ranges for combined use with PI-RADS. Results Overall, 260 men (median age, 64 years [IQR, 58-69 years]) with 432 lesions (csPCa [n = 152] and no csPCa [n = 280]) were included. The mDCE parameter was predictive of csPCa when accounting for the ADC and nT2 parameter in the peripheral zone (odds ratio [OR], 1.76; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:35972360
DO  - DOI:10.1148/radiol.212692
UR  - https://inrepo02.dkfz.de/record/181233
ER  -