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000181246 0247_ $$2doi$$a10.1111/nan.12847
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000181246 037__ $$aDKFZ-2022-01892
000181246 041__ $$aEnglish
000181246 082__ $$a610
000181246 1001_ $$0P:(DE-He78)856d5c1d0205a79190ed88218ffaf9b2$$aReinhardt, Annekathrin$$b0$$eFirst author$$udkfz
000181246 245__ $$aAnaplastic ganglioglioma - a diagnosis comprising several distinct tumour types.
000181246 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2022
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000181246 500__ $$a#EA:B300#LA:B300# / 2022 Dec;48(7):e12847
000181246 520__ $$aAnaplastic ganglioglioma is a rare tumour and diagnosis has been based on histological criteria. The 5th edition of the World Health Organization Classification of Tumours of the Central Nervous System (CNS WHO) does not list anaplastic ganglioglioma as a distinct diagnosis due to lack of molecular data in previous publications AIM: We retrospectively compiled a cohort of 54 histologically diagnosed anaplastic gangliogliomas to explore whether the molecular profiles of these tumours represent a separate type or resolve into other entities METHODS: Samples were subjected to histological review, DNA methylation profiling and next generation sequencing. Morphologic and molecular data were summarised to an integrated diagnosis RESULTS: The majority of histologically diagnosed anaplastic gangliogliomas resolved into CNS WHO diagnoses of glial tumours, most commonly pleomorphic xanthoastrocytoma (16/54), glioblastoma, IDH wildtype and diffuse paediatric-type high-grade glioma, H3 wildtype and IDH wildtype (11 and 2/54) followed by low-grade glial or glioneuronal tumours including pilocytic astrocytoma, dysembryoplastic neuroepithelial tumour and diffuse leptomeningeal glioneuronal tumour (5/54), IDH mutant astrocytoma (4/54) and others (6/54). A subset of tumours (10/54) was not assignable to a CNS WHO diagnosis and common molecular profiles pointing to a separate entity were not evident CONCLUSION: In summary, we show that tumours histologically diagnosed as anaplastic ganglioglioma comprise a wide spectrum of CNS WHO tumour types with different prognostic and therapeutic implications. We therefore suggest assigning this designation with caution and recommend comprehensive molecular workup.
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000181246 650_7 $$2Other$$aDNA methylation analysis
000181246 650_7 $$2Other$$aanaplastic ganglioglioma
000181246 650_7 $$2Other$$aganglioglioma
000181246 650_7 $$2Other$$amethylation class
000181246 650_7 $$2Other$$amolecular glioma entities
000181246 650_7 $$2Other$$amolecular neuropathology
000181246 7001_ $$0P:(DE-HGF)0$$aPfister, Kristin$$b1
000181246 7001_ $$0P:(DE-He78)e54a1e0999c1d8c95869ef9188b794cc$$aSchrimpf, Daniel$$b2$$udkfz
000181246 7001_ $$0P:(DE-He78)d20d08adc992abdb6ccffa1686f1ba17$$aStichel, Damian$$b3$$udkfz
000181246 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b4$$udkfz
000181246 7001_ $$0P:(DE-HGF)0$$aReuss, David E$$b5
000181246 7001_ $$0P:(DE-He78)51bf9ae9cb5771b30c483e5597ef606c$$aCapper, David$$b6$$udkfz
000181246 7001_ $$0P:(DE-He78)32977c5abc127b0373ece54294a41f63$$aWefers, Annika$$b7
000181246 7001_ $$0P:(DE-He78)c1e6f8388afe92ba3e13be35e7bf54d8$$aEbrahimi, Azadeh$$b8$$udkfz
000181246 7001_ $$0P:(DE-He78)45440b44791309bd4b7dbb4f73333f9b$$aSill, Martin$$b9$$udkfz
000181246 7001_ $$aFelsberg, Joerg$$b10
000181246 7001_ $$0P:(DE-HGF)0$$aReifenberger, Guido$$b11
000181246 7001_ $$00000-0003-2661-3705$$aBecker, Albert$$b12
000181246 7001_ $$aPrinz, Marco$$b13
000181246 7001_ $$aStaszewski, Ori$$b14
000181246 7001_ $$aHartmann, Christian$$b15
000181246 7001_ $$00000-0002-9168-6209$$aSchittenhelm, Jens$$b16
000181246 7001_ $$aGramatzki, Dorothee$$b17
000181246 7001_ $$aWeller, Michael$$b18
000181246 7001_ $$aOlar, Adriana$$b19
000181246 7001_ $$aRushing, Elisabeth Jane$$b20
000181246 7001_ $$aBergmann, Markus$$b21
000181246 7001_ $$aFarrell, Michael A$$b22
000181246 7001_ $$aBlümcke, Ingmar$$b23
000181246 7001_ $$aCoras, Roland$$b24
000181246 7001_ $$aBeckervordersandforth, Jan$$b25
000181246 7001_ $$aKim, Se Hoon$$b26
000181246 7001_ $$aRogerio, Fabio$$b27
000181246 7001_ $$aDimova, Petia S$$b28
000181246 7001_ $$00000-0002-3247-5241$$aNiehusmann, Pitt$$b29
000181246 7001_ $$aUnterberg, Andreas$$b30
000181246 7001_ $$0P:(DE-He78)5ef8651b0f857b9c640aa5b1498c43b5$$aPlatten, Michael$$b31$$udkfz
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000181246 7001_ $$0P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aWick, Wolfgang$$b33$$udkfz
000181246 7001_ $$aHerold-Mende, Christel$$b34
000181246 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, Andreas$$b35$$eLast author$$udkfz
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