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@ARTICLE{Reinhardt:181246,
      author       = {A. Reinhardt$^*$ and K. Pfister$^*$ and D. Schrimpf$^*$ and
                      D. Stichel$^*$ and F. Sahm$^*$ and D. E. Reuss$^*$ and D.
                      Capper$^*$ and A. Wefers$^*$ and A. Ebrahimi$^*$ and M.
                      Sill$^*$ and J. Felsberg and G. Reifenberger$^*$ and A.
                      Becker and M. Prinz and O. Staszewski and C. Hartmann and J.
                      Schittenhelm and D. Gramatzki and M. Weller and A. Olar and
                      E. J. Rushing and M. Bergmann and M. A. Farrell and I.
                      Blümcke and R. Coras and J. Beckervordersandforth and S. H.
                      Kim and F. Rogerio and P. S. Dimova and P. Niehusmann and A.
                      Unterberg and M. Platten$^*$ and S. Pfister$^*$ and W.
                      Wick$^*$ and C. Herold-Mende and A. von Deimling$^*$},
      title        = {{A}naplastic ganglioglioma - a diagnosis comprising several
                      distinct tumour types.},
      journal      = {Neuropathology $\&$ applied neurobiology},
      volume       = {48},
      number       = {7},
      issn         = {0305-1846},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2022-01892},
      pages        = {e12847},
      year         = {2022},
      note         = {#EA:B300#LA:B300# / 2022 Dec;48(7):e12847},
      abstract     = {Anaplastic ganglioglioma is a rare tumour and diagnosis has
                      been based on histological criteria. The 5th edition of the
                      World Health Organization Classification of Tumours of the
                      Central Nervous System (CNS WHO) does not list anaplastic
                      ganglioglioma as a distinct diagnosis due to lack of
                      molecular data in previous publications AIM: We
                      retrospectively compiled a cohort of 54 histologically
                      diagnosed anaplastic gangliogliomas to explore whether the
                      molecular profiles of these tumours represent a separate
                      type or resolve into other entities METHODS: Samples were
                      subjected to histological review, DNA methylation profiling
                      and next generation sequencing. Morphologic and molecular
                      data were summarised to an integrated diagnosis RESULTS: The
                      majority of histologically diagnosed anaplastic
                      gangliogliomas resolved into CNS WHO diagnoses of glial
                      tumours, most commonly pleomorphic xanthoastrocytoma
                      (16/54), glioblastoma, IDH wildtype and diffuse
                      paediatric-type high-grade glioma, H3 wildtype and IDH
                      wildtype (11 and 2/54) followed by low-grade glial or
                      glioneuronal tumours including pilocytic astrocytoma,
                      dysembryoplastic neuroepithelial tumour and diffuse
                      leptomeningeal glioneuronal tumour (5/54), IDH mutant
                      astrocytoma (4/54) and others (6/54). A subset of tumours
                      (10/54) was not assignable to a CNS WHO diagnosis and common
                      molecular profiles pointing to a separate entity were not
                      evident CONCLUSION: In summary, we show that tumours
                      histologically diagnosed as anaplastic ganglioglioma
                      comprise a wide spectrum of CNS WHO tumour types with
                      different prognostic and therapeutic implications. We
                      therefore suggest assigning this designation with caution
                      and recommend comprehensive molecular workup.},
      keywords     = {DNA methylation analysis (Other) / anaplastic ganglioglioma
                      (Other) / ganglioglioma (Other) / methylation class (Other)
                      / molecular glioma entities (Other) / molecular
                      neuropathology (Other)},
      cin          = {B300 / BE01 / HD01 / ED01 / D170 / B062 / B320},
      ddc          = {610},
      cid          = {I:(DE-He78)B300-20160331 / I:(DE-He78)BE01-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)ED01-20160331 /
                      I:(DE-He78)D170-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)B320-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35977725},
      doi          = {10.1111/nan.12847},
      url          = {https://inrepo02.dkfz.de/record/181246},
}