| 001 | 181321 | ||
| 005 | 20240419142049.0 | ||
| 024 | 7 | _ | |a 10.1016/j.annonc.2022.07.008 |2 doi |
| 024 | 7 | _ | |a pmid:35988656 |2 pmid |
| 024 | 7 | _ | |a 0923-7534 |2 ISSN |
| 024 | 7 | _ | |a 1569-8041 |2 ISSN |
| 024 | 7 | _ | |a altmetric:134730273 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2022-01948 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Jahn, Arne |0 P:(DE-He78)871753841be6a28f30e6fc8c4fa324f7 |b 0 |e First author |
| 245 | _ | _ | |a Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers. |
| 260 | _ | _ | |a Amsterdam [u.a. |c 2022 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1713529135_17806 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2022 Nov;33(11):1186-1199 |
| 520 | _ | _ | |a Germline variant evaluation in precision oncology opens new paths towards the identification of patients with genetic tumor risk syndromes and the exploration of therapeutic relevance. Here, we present the results of germline variant analysis and their clinical implications in a precision oncology study for patients with predominantly rare cancers.Matched tumor and control genome/exome and RNA sequencing was performed for 1,485 patients with rare cancers (79%) and/or young adults (77% younger than 51 years) in the NCT/DKTK MASTER trial, a German multicenter, prospective observational precision oncology study. Clinical and therapeutic relevance of prospective pathogenic germline variant (PGV) evaluation was analyzed and compared to other precision oncology studies.Ten percent of patients (n=157) harbored PGVs in 35 genes associated with autosomal dominant cancer predisposition, whereof up to 75% were unknown before study participation. Another five percent of patients (n=75) were heterozygous carriers for recessive genetic tumor risk syndromes. Particularly high PGV yields were found in patients with gastrointestinal stromal tumors (GISTs) (28%, 11/40), and more specific in wild-type GISTS (50%, n=10/20), leiomyosarcomas (21%, n=19/89), and hepatopancreaticobiliary cancers (16%, n=16/97). Forty-five percent of PGVs (n=100/221) supported treatment recommendations, and its implementation led to a clinical benefit in 40% of patients (n=10/25). A comparison of different precision oncology studies revealed variable PGV yields and considerable differences in germline variant analysis workflows. We therefore propose a detailed workflow for germline variant evaluation.Genetic germline testing in patients with rare cancers can identify the very first patient in a hereditary cancer family and can lead to clinical benefit in a broad range of entities. Its routine implementation in precision oncology accompanied by the harmonization of germline variant evaluation workflows will increase clinical benefit and boost research. |
| 536 | _ | _ | |a 312 - Funktionelle und strukturelle Genomforschung (POF4-312) |0 G:(DE-HGF)POF4-312 |c POF4-312 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 7 | |a biomarker |2 Other |
| 650 | _ | 7 | |a hereditary cancer |2 Other |
| 650 | _ | 7 | |a precision medicine |2 Other |
| 650 | _ | 7 | |a prevention |2 Other |
| 650 | _ | 7 | |a rare cancer |2 Other |
| 650 | _ | 7 | |a targeted therapy |2 Other |
| 700 | 1 | _ | |a Rump, A. |0 P:(DE-HGF)0 |b 1 |e First author |
| 700 | 1 | _ | |a Widmann, Thomas |0 P:(DE-He78)303abb94346aa2fb80157f74a3e21d9d |b 2 |e First author |
| 700 | 1 | _ | |a Heining, Christoph |0 P:(DE-He78)1464357f7ec5faf677a390a414e50c88 |b 3 |
| 700 | 1 | _ | |a Horak, Peter |0 P:(DE-He78)5ea1944c122bc098a81df27a05572719 |b 4 |
| 700 | 1 | _ | |a Hutter, Barbara |0 P:(DE-He78)135e8c8d1dd1b66b8127c3d1e3a9b6a0 |b 5 |
| 700 | 1 | _ | |a Paramasivam, Nagarajan |0 P:(DE-He78)4a8b73f9f05542860120bb0e19527fd2 |b 6 |
| 700 | 1 | _ | |a Uhrig, Sebastian |0 P:(DE-He78)a8e85c1bd89741ab0c2a28032ba81359 |b 7 |
| 700 | 1 | _ | |a Gieldon, L. |b 8 |
| 700 | 1 | _ | |a Drukewitz, Stephan |0 P:(DE-He78)151d1420b283927835ebfcd699fe042e |b 9 |
| 700 | 1 | _ | |a Kübler, A. |b 10 |
| 700 | 1 | _ | |a Bermudez, M. |b 11 |
| 700 | 1 | _ | |a Hackmann, K. |b 12 |
| 700 | 1 | _ | |a Porrmann, J. |b 13 |
| 700 | 1 | _ | |a Wagner, J. |b 14 |
| 700 | 1 | _ | |a Arlt, M. |b 15 |
| 700 | 1 | _ | |a Franke, M. |b 16 |
| 700 | 1 | _ | |a Fischer, J. |b 17 |
| 700 | 1 | _ | |a Kowalzyk, Z. |b 18 |
| 700 | 1 | _ | |a William, Doreen |0 P:(DE-He78)fd820a2b4461bddd116c1518bc4b0f77 |b 19 |
| 700 | 1 | _ | |a Weth, V. |b 20 |
| 700 | 1 | _ | |a Oster, Sandra |0 P:(DE-He78)2b9a9d9cc2ba961360ce5b9a67c4c74d |b 21 |
| 700 | 1 | _ | |a Fröhlich, Martina Antonia |0 P:(DE-He78)a15aa7d740f286aad9d8139d515e866c |b 22 |
| 700 | 1 | _ | |a Hüllein, Jennifer |0 P:(DE-He78)c9be4ab60d1090c3d315a2ca6905e9ea |b 23 |
| 700 | 1 | _ | |a Valle González, C. |0 P:(DE-HGF)0 |b 24 |
| 700 | 1 | _ | |a Kreutzfeldt, Simon |0 P:(DE-He78)e5972dddc3c8d1412db29ba54fed83ba |b 25 |
| 700 | 1 | _ | |a Mock, Andreas |0 P:(DE-He78)8f7c3bc1451193551c2458d93222536a |b 26 |
| 700 | 1 | _ | |a Heilig, Christoph |0 P:(DE-He78)42b6114cd48e033299b2b6ef4bf56cc6 |b 27 |
| 700 | 1 | _ | |a Lipka, Daniel |0 P:(DE-He78)c403a040c97f91902a7d31b93859f9fc |b 28 |
| 700 | 1 | _ | |a Möhrmann, Lino |0 P:(DE-He78)79e92bc6260b7a24abe4daf4378bf19c |b 29 |
| 700 | 1 | _ | |a Hanf, Dorothea |0 P:(DE-He78)36e79cd7c1ac7dfe060c02dbfdaff3c4 |b 30 |
| 700 | 1 | _ | |a Teleanu, Maria-Veronica |0 P:(DE-He78)4e4e534b615747750de8b9a7afdd8f56 |b 31 |
| 700 | 1 | _ | |a Allgäuer, M. |b 32 |
| 700 | 1 | _ | |a Ruhnke, L. |b 33 |
| 700 | 1 | _ | |a Kutz, O. |b 34 |
| 700 | 1 | _ | |a Knurr, Alexander |0 P:(DE-He78)d86248f91d13930d4a6ee02207362576 |b 35 |
| 700 | 1 | _ | |a Laßmann, Andreas |0 P:(DE-He78)b8abad9321b77c1f712c979f195cba2d |b 36 |
| 700 | 1 | _ | |a Endris, V. |b 37 |
| 700 | 1 | _ | |a Neumann, O. |b 38 |
| 700 | 1 | _ | |a Penzel, R. |b 39 |
| 700 | 1 | _ | |a Beck, Katja |0 P:(DE-He78)f6b238ac374345c55706521c4f435779 |b 40 |
| 700 | 1 | _ | |a Richter, Daniela |0 P:(DE-He78)29306fd3ae9f1a9839ed888ebc5c8074 |b 41 |
| 700 | 1 | _ | |a Winter, Ulrike |0 P:(DE-He78)1c8d58457eef78f08327c632afb8f13f |b 42 |
| 700 | 1 | _ | |a Wolf, Stephan |0 P:(DE-He78)1efb774993effe7a66a6ffc1b1cf9ccb |b 43 |
| 700 | 1 | _ | |a Pfütze, Katrin |0 P:(DE-He78)83906db1355a576371363a4b9f107d3d |b 44 |
| 700 | 1 | _ | |a Geörg, Christina |0 P:(DE-He78)3f888debb126ff36634df058ccaaf2b4 |b 45 |
| 700 | 1 | _ | |a Meissburger, Bettina |0 P:(DE-He78)9437a8b804d8cc2481997716ec66fa2f |b 46 |
| 700 | 1 | _ | |a Buchhalter, Ivo |0 P:(DE-He78)e84b3187ddd3529f884082e30f228c66 |b 47 |
| 700 | 1 | _ | |a Augustin, M. |b 48 |
| 700 | 1 | _ | |a Aulitzky, W. E. |b 49 |
| 700 | 1 | _ | |a Hohenberger, P. |b 50 |
| 700 | 1 | _ | |a Kroiss, M. |b 51 |
| 700 | 1 | _ | |a Schirmacher, Peter |0 P:(DE-He78)95cce409faf956f2db2a954a59d70ec7 |b 52 |
| 700 | 1 | _ | |a Schlenk, Richard |0 P:(DE-He78)d8a0e60e5e095f3161ee0de3712409bc |b 53 |
| 700 | 1 | _ | |a Keilholz, Ulrich |0 P:(DE-He78)db014277a1d4005afd93fa95bc6a1001 |b 54 |
| 700 | 1 | _ | |a Klauschen, F. |0 P:(DE-HGF)0 |b 55 |
| 700 | 1 | _ | |a Folprecht, G. |0 P:(DE-HGF)0 |b 56 |
| 700 | 1 | _ | |a Bauer, S. |0 P:(DE-HGF)0 |b 57 |
| 700 | 1 | _ | |a Siveke, Jens |0 P:(DE-He78)026e0a55b968f360a3c349689ce8a99c |b 58 |
| 700 | 1 | _ | |a Brandts, C. H. |0 P:(DE-HGF)0 |b 59 |
| 700 | 1 | _ | |a Kindler, T. |0 P:(DE-HGF)0 |b 60 |
| 700 | 1 | _ | |a Börries, Melanie |0 P:(DE-He78)49bdb7cb4094fbf35c269ffa3e93ebc6 |b 61 |
| 700 | 1 | _ | |a Illert, A. L. |0 P:(DE-HGF)0 |b 62 |
| 700 | 1 | _ | |a von Bubnoff, N. |b 63 |
| 700 | 1 | _ | |a Jost, P. J. |0 P:(DE-HGF)0 |b 64 |
| 700 | 1 | _ | |a Metzeler, K. H. |b 65 |
| 700 | 1 | _ | |a Bitzer, M. |0 P:(DE-HGF)0 |b 66 |
| 700 | 1 | _ | |a Schulze Osthoff, Klaus |0 P:(DE-He78)3fc9ad1c0cc7a2172b86374faed6edea |b 67 |
| 700 | 1 | _ | |a von Kalle, C. |b 68 |
| 700 | 1 | _ | |a Brors, Benedikt |0 P:(DE-He78)fc949170377b58098e46141d95c72661 |b 69 |
| 700 | 1 | _ | |a Stenzinger, A. |0 P:(DE-HGF)0 |b 70 |
| 700 | 1 | _ | |a Weichert, Wilko |0 P:(DE-He78)891da714b7f7991d9c4c1d5224c991e7 |b 71 |
| 700 | 1 | _ | |a Hübschmann, Daniel |0 P:(DE-He78)a5218e4871866cd5ab2312e594ca403d |b 72 |
| 700 | 1 | _ | |a Fröhling, Stefan |0 P:(DE-He78)f0144d171d26dbedb67c9db1df35629d |b 73 |e Last author |
| 700 | 1 | _ | |a Glimm, Hanno |0 P:(DE-He78)157277fe62f07df1732f9d126a51d1b9 |b 74 |e Last author |
| 700 | 1 | _ | |a Schröck, E. |0 P:(DE-HGF)0 |b 75 |e Last author |
| 700 | 1 | _ | |a Klink, B. |0 P:(DE-HGF)0 |b 76 |e Last author |
| 773 | _ | _ | |a 10.1016/j.annonc.2022.07.008 |g p. S0923753422018592 |0 PERI:(DE-600)2003498-2 |n 11 |p 1186-1199 |t Annals of oncology |v 33 |y 2022 |x 0923-7534 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:181321 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 0 |6 P:(DE-He78)871753841be6a28f30e6fc8c4fa324f7 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 1 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)303abb94346aa2fb80157f74a3e21d9d |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 3 |6 P:(DE-He78)1464357f7ec5faf677a390a414e50c88 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 4 |6 P:(DE-He78)5ea1944c122bc098a81df27a05572719 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 5 |6 P:(DE-He78)135e8c8d1dd1b66b8127c3d1e3a9b6a0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 6 |6 P:(DE-He78)4a8b73f9f05542860120bb0e19527fd2 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 7 |6 P:(DE-He78)a8e85c1bd89741ab0c2a28032ba81359 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 9 |6 P:(DE-He78)151d1420b283927835ebfcd699fe042e |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 19 |6 P:(DE-He78)fd820a2b4461bddd116c1518bc4b0f77 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 21 |6 P:(DE-He78)2b9a9d9cc2ba961360ce5b9a67c4c74d |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 22 |6 P:(DE-He78)a15aa7d740f286aad9d8139d515e866c |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 23 |6 P:(DE-He78)c9be4ab60d1090c3d315a2ca6905e9ea |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 24 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 25 |6 P:(DE-He78)e5972dddc3c8d1412db29ba54fed83ba |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 26 |6 P:(DE-He78)8f7c3bc1451193551c2458d93222536a |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 27 |6 P:(DE-He78)42b6114cd48e033299b2b6ef4bf56cc6 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 28 |6 P:(DE-He78)c403a040c97f91902a7d31b93859f9fc |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 29 |6 P:(DE-He78)79e92bc6260b7a24abe4daf4378bf19c |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 30 |6 P:(DE-He78)36e79cd7c1ac7dfe060c02dbfdaff3c4 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 31 |6 P:(DE-He78)4e4e534b615747750de8b9a7afdd8f56 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 35 |6 P:(DE-He78)d86248f91d13930d4a6ee02207362576 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 36 |6 P:(DE-He78)b8abad9321b77c1f712c979f195cba2d |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 40 |6 P:(DE-He78)f6b238ac374345c55706521c4f435779 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 41 |6 P:(DE-He78)29306fd3ae9f1a9839ed888ebc5c8074 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 42 |6 P:(DE-He78)1c8d58457eef78f08327c632afb8f13f |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 43 |6 P:(DE-He78)1efb774993effe7a66a6ffc1b1cf9ccb |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 44 |6 P:(DE-He78)83906db1355a576371363a4b9f107d3d |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 45 |6 P:(DE-He78)3f888debb126ff36634df058ccaaf2b4 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 46 |6 P:(DE-He78)9437a8b804d8cc2481997716ec66fa2f |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 47 |6 P:(DE-He78)e84b3187ddd3529f884082e30f228c66 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 52 |6 P:(DE-He78)95cce409faf956f2db2a954a59d70ec7 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 53 |6 P:(DE-He78)d8a0e60e5e095f3161ee0de3712409bc |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 54 |6 P:(DE-He78)db014277a1d4005afd93fa95bc6a1001 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 55 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 56 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 57 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 58 |6 P:(DE-He78)026e0a55b968f360a3c349689ce8a99c |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 59 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 60 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 61 |6 P:(DE-He78)49bdb7cb4094fbf35c269ffa3e93ebc6 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 62 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 64 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 66 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 67 |6 P:(DE-He78)3fc9ad1c0cc7a2172b86374faed6edea |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 69 |6 P:(DE-He78)fc949170377b58098e46141d95c72661 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 70 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 71 |6 P:(DE-He78)891da714b7f7991d9c4c1d5224c991e7 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 72 |6 P:(DE-He78)a5218e4871866cd5ab2312e594ca403d |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 73 |6 P:(DE-He78)f0144d171d26dbedb67c9db1df35629d |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 74 |6 P:(DE-He78)157277fe62f07df1732f9d126a51d1b9 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 75 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 76 |6 P:(DE-HGF)0 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-312 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Funktionelle und strukturelle Genomforschung |x 0 |
| 914 | 1 | _ | |y 2022 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-01-28 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-01-28 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-09 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-09 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-09 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-09 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2022-11-09 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b ANN ONCOL : 2021 |d 2022-11-09 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2022-11-09 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2022-11-09 |
| 915 | _ | _ | |a IF >= 50 |0 StatID:(DE-HGF)9950 |2 StatID |b ANN ONCOL : 2021 |d 2022-11-09 |
| 920 | 1 | _ | |0 I:(DE-He78)DD01-20160331 |k DD01 |l DKTK Koordinierungsstelle Dresden |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)HD01-20160331 |k HD01 |l DKTK HD zentral |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)B340-20160331 |k B340 |l Translationale Medizinische Onkologie |x 2 |
| 920 | 1 | _ | |0 I:(DE-He78)B330-20160331 |k B330 |l Angewandte Bioinformatik |x 3 |
| 920 | 1 | _ | |0 I:(DE-He78)M130-20160331 |k M130 |l Clinical Trial Office |x 4 |
| 920 | 1 | _ | |0 I:(DE-He78)W190-20160331 |k W190 |l Hochdurchsatz-Sequenzierung |x 5 |
| 920 | 1 | _ | |0 I:(DE-He78)W610-20160331 |k W610 |l Core Facility Omics IT |x 6 |
| 920 | 1 | _ | |0 I:(DE-He78)BE01-20160331 |k BE01 |l DKTK Koordinierungsstelle Berlin |x 7 |
| 920 | 1 | _ | |0 I:(DE-He78)ED01-20160331 |k ED01 |l DKTK Koordinierungsstelle Essen/Düsseldorf |x 8 |
| 920 | 1 | _ | |0 I:(DE-He78)FM01-20160331 |k FM01 |l DKTK Koordinierungsstelle Frankfurt |x 9 |
| 920 | 1 | _ | |0 I:(DE-He78)FR01-20160331 |k FR01 |l DKTK Koordinierungsstelle Freiburg |x 10 |
| 920 | 1 | _ | |0 I:(DE-He78)MU01-20160331 |k MU01 |l DKTK Koordinierungsstelle München |x 11 |
| 920 | 1 | _ | |0 I:(DE-He78)TU01-20160331 |k TU01 |l DKTK Koordinierungsstelle Tübingen |x 12 |
| 920 | 1 | _ | |0 I:(DE-He78)W010-20160331 |k W010 |l Klinische Studienzentrale |x 13 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)DD01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)HD01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B340-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B330-20160331 |
| 980 | _ | _ | |a I:(DE-He78)M130-20160331 |
| 980 | _ | _ | |a I:(DE-He78)W190-20160331 |
| 980 | _ | _ | |a I:(DE-He78)W610-20160331 |
| 980 | _ | _ | |a I:(DE-He78)BE01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)ED01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)FM01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)FR01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)MU01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)TU01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)W010-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|
guest ::