%0 Journal Article
%A Gregg, Justin R
%A Kim, Jeri
%A Logothetis, Christopher
%A Hanash, Sam
%A Zhang, Xiaotao
%A Manyam, Ganiraju
%A Muir, Kenneth
%A Giles, Graham G
%A Stanford, Janet L
%A Berndt, Sonja I
%A Kogevinas, Manolis
%A Brenner, Hermann
%A Eeles, Rosalind A
%A Wei, Peng
%A Daniel, Carrie R
%T Coffee Intake, Caffeine Metabolism Genotype, and Survival Among Men with Prostate Cancer.
%J European urology oncology
%V 6
%N 3
%@ 2588-9311
%C Amsterdam
%I Elsevier
%M DKFZ-2022-01964
%P 282-288
%D 2023
%Z 2023 Jun;6(3):282-288
%X Coffee intake may lower prostate cancer risk and progression, but postdiagnosis outcomes by caffeine metabolism genotype are not well characterized.To evaluate associations between coffee intake, caffeine metabolism genotype, and survival in a large, multicenter study of men with prostate cancer.Data from The PRACTICAL Consortium database for 5727 men with prostate cancer from seven US, Australian, and European studies were included. The cases included had data available for the CYP1A2 -163C>A rs762551 single-nucleotide variant associated with caffeine metabolism, coffee intake, and >6 mo of follow-up.Multivariable-adjusted Cox proportional hazards models across pooled patient-level data were used to compare the effect of coffee intake (categorized as low [reference], high, or none/very low) in relation to overall survival (OS) and prostate cancer-specific survival (PCSS), with stratified analyses conducted by clinical disease risk and genotype.High coffee intake appeared to be associated with longer PCSS (hazard ratio [HR] 0.85, 95
%K Caffeine (Other)
%K Coffee (Other)
%K Genetic variation (Other)
%K Mortality (Other)
%K Prostatic neoplasms (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35995710
%R 10.1016/j.euo.2022.07.008
%U https://inrepo02.dkfz.de/record/181396