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| Home > Publications database > Assessing muscle-specific potassium concentrations in human lower leg using 39 K MRI. > print |
| 001 | 181398 | ||
| 005 | 20240229145646.0 | ||
| 024 | 7 | _ | |a 10.1002/nbm.4819 |2 doi |
| 024 | 7 | _ | |a pmid:35994248 |2 pmid |
| 024 | 7 | _ | |a 0952-3480 |2 ISSN |
| 024 | 7 | _ | |a 1099-1492 |2 ISSN |
| 024 | 7 | _ | |a altmetric:134872429 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2022-01966 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Gast, Lena V |0 0000-0002-4599-1122 |b 0 |
| 245 | _ | _ | |a Assessing muscle-specific potassium concentrations in human lower leg using 39 K MRI. |
| 260 | _ | _ | |a New York, NY |c 2023 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1670585596_24789 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #LA:E020# / 2023 Jan;36(1):e4819 |
| 520 | _ | _ | |a Non-invasively assessing tissue potassium concentrations (TPC) using 39 K MRI could give valuable information on physiological processes connected to various pathologies. However, due to inherently low 39 K MR image resolution and strong signal blurring, a reliable measurement of the TPC is challenging. The aim of this work was to investigate the feasibility of a muscle-specific TPC determination with focus on the influence of a varying residual quadrupolar interaction in human lower leg muscles.The quantification accuracy of a muscle-specific TPC determination was first assessed using simulated 39 K MRI data. In vivo 39 K and corresponding 23 Na MRI data of healthy lower leg muscles (n=14, 7 female) were acquired on a 7T MR system using a double-resonant 23 Na/39 K birdcage Tx/Rx RF coil. Additional 1 H MR images were acquired at a 3T MR system and used for tissue segmentation. Quantification of TPC was performed after a region-based partial volume correction (PVC) using five external reference phantoms.Simulations not only underlined the importance of a PVC for correctly assessing muscle-specific TPC values, but also revealed a strong impact of a varying residual quadrupolar interaction between different muscle regions on the measured TPC. Using 39 K T2 * decay curves, we found a significantly higher residual quadrupolar interaction in tibialis anterior muscle (TA, ωq = 194±28 Hz) compared to gastrocnemius muscle (medial/lateral head, GM/GL, ωq = 151±25 Hz), and soleus muscle (SOL, ωq = 102±32 Hz). If considered in the PVC, TPC in individual muscles was similar (TPC= 98±11/96±14/99±8/100±12 mM in GM/GL/SOL/TA). Comparison with tissue sodium concentrations suggested that residual quadrupolar interactions might also influence the 23 Na MRI signal of lower leg muscles.A TPC determination of individual lower leg muscles is feasible and can therefore be applied in future studies. Considering a varying residual quadrupolar interaction for PVC of 39 K MRI data is essential to reliably assess potassium concentrations in individual muscles. |
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| 650 | _ | 7 | |a 7 Tesla |2 Other |
| 650 | _ | 7 | |a muscle MRI |2 Other |
| 650 | _ | 7 | |a potassium (39K) MRI |2 Other |
| 650 | _ | 7 | |a sodium (23Na) MRI |2 Other |
| 650 | _ | 7 | |a tissue potassium concentration |2 Other |
| 650 | _ | 7 | |a tissue sodium concentration |2 Other |
| 650 | _ | 7 | |a ultrahigh field strengths |2 Other |
| 700 | 1 | _ | |a Baier, Laura-Marie |b 1 |
| 700 | 1 | _ | |a Chaudry, Oliver |b 2 |
| 700 | 1 | _ | |a Meixner, Christian R |b 3 |
| 700 | 1 | _ | |a Müller, Max |b 4 |
| 700 | 1 | _ | |a Engelke, Klaus |b 5 |
| 700 | 1 | _ | |a Uder, Michael |b 6 |
| 700 | 1 | _ | |a Heiss, Rafael |0 0000-0002-2897-5411 |b 7 |
| 700 | 1 | _ | |a Nagel, Armin |0 P:(DE-He78)054fd7a5195b75b11fbdc5c360276011 |b 8 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1002/nbm.4819 |0 PERI:(DE-600)2002003-X |n 1 |p e4819 |t NMR in biomedicine |v 36 |y 2023 |x 0952-3480 |
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| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 8 |6 P:(DE-He78)054fd7a5195b75b11fbdc5c360276011 |
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| 914 | 1 | _ | |y 2022 |
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