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@ARTICLE{Koerber:181428,
      author       = {S. A. Koerber$^*$ and R. C. Kroener and K. Dendl and C.
                      Kratochwil$^*$ and C. A. Fink and J. Ristau and E. Winter
                      and K. Herfarth and G. Hatiboglu and M. Hohenfellner and U.
                      Haberkorn$^*$ and J. Debus$^*$ and F. L. Giesel},
      title        = {{D}etecting and {L}ocating the {S}ite of {L}ocal {R}elapse
                      {U}sing 18{F}-{PSMA}-1007 {I}maging {A}fter {P}rimary
                      {T}reatment of 135 {P}rostate {C}ancer
                      {P}atients-{P}otential {I}mpact on {PSMA}-{G}uided
                      {R}adiation {T}herapy.},
      journal      = {Molecular imaging $\&$ biology},
      volume       = {25},
      number       = {2},
      issn         = {1536-1632},
      address      = {Cham},
      publisher    = {Springer Nature Switzerland},
      reportid     = {DKFZ-2022-01996},
      pages        = {375-383},
      year         = {2023},
      note         = {#EA:E050# / 2023 Apr;25(2):375-383},
      abstract     = {Due to limited imaging options, the visualization of a
                      local relapse of prostate cancer used to pose a considerable
                      challenge. However, since the integration of
                      18F-PSMA-1007-PET/CT into the clinic, a relapsed tumor can
                      now easily be detected by hybrid imaging. The present study
                      aimed to evaluate and map the allocate relapse in a large
                      cohort of prostate cancer patients focusing on individual
                      patient management conclusions for radiation therapy.The
                      current study included 135 men with prostate cancer after
                      primary treatment who underwent 18F-PSMA-1007-PET/CT due to
                      biochemical relapse detecting a local relapse. Imaging data
                      were reassessed and analyzed with regard to relapse
                      locations. For the correlation of tumor foci with clinical
                      data, we used binary logistic regression models as well as
                      the Kruskal-Wallis test and Mann-Whitney test.In total,
                      $69.6\%$ of all patients (mean age: 65 years) underwent
                      prostatectomy while $30.4\%$ underwent radiation therapy.
                      PET imaging detected most frequently a unifocal relapse
                      $(72.6\%).$ There was a statistically significantly higher
                      rate of ipsilateral cases among the relapsed tumors.
                      Comparing both treatment approaches, tumors relapsed most
                      commonly within the posterior region after surgery and
                      transition/peripheral zone after radiation therapy,
                      respectively.The present study confirms that
                      18F-PSMA-1007-PET/CT is highly suitable for the localization
                      and allocation of a local relapse in patients with prostate
                      cancer. The data enable further optimizing dose
                      prescriptions and target volume delineations of radiation
                      therapy in the future.},
      keywords     = {18F-PSMA-1007 (Other) / Local relapse (Other) / PET/CT
                      (Other) / PSMA (Other) / Prostate cancer (Other)},
      cin          = {E050 / E060 / HD01},
      ddc          = {570},
      cid          = {I:(DE-He78)E050-20160331 / I:(DE-He78)E060-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35999425},
      doi          = {10.1007/s11307-022-01766-6},
      url          = {https://inrepo02.dkfz.de/record/181428},
}