TY  - JOUR
AU  - Grenville, Zoe S
AU  - Noor, Urwah
AU  - His, Mathilde
AU  - Viallon, Vivian
AU  - Rinaldi, Sabina
AU  - Aglago, Elom K
AU  - Amiano, Pilar
AU  - Brunkwall, Louise
AU  - Chirlaque, María Dolores
AU  - Drake, Isabel
AU  - Eichelmann, Fabian
AU  - Freisling, Heinz
AU  - Grioni, Sara
AU  - Heath, Alicia K
AU  - Kaaks, Rudolf
AU  - Katzke, Verena
AU  - Mayén-Chacon, Ana-Lucia
AU  - Milani, Lorenzo
AU  - Moreno-Iribas, Conchi
AU  - Pala, Valeria
AU  - Olsen, Anja
AU  - Sánchez, Maria-Jose
AU  - Schulze, Matthias B
AU  - Tjønneland, Anne
AU  - Tsilidis, Konstantinos K
AU  - Weiderpass, Elisabete
AU  - Winkvist, Anna
AU  - Zamora-Ros, Raul
AU  - Key, Timothy J
AU  - Smith-Byrne, Karl
AU  - Travis, Ruth C
AU  - Schmidt, Julie A
TI  - Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer.
JO  - Nutrients
VL  - 14
IS  - 16
SN  - 2072-6643
CY  - Basel
PB  - MDPI
M1  - DKFZ-2022-02027
SP  - 3306
PY  - 2022
AB  - Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern 1), acylcarnitines C18:1 and C18:2, glutamate, ornithine, and taurine (Pattern 2), and 8 lysophosphatidylcholines (Pattern 3). In a two-stage cross-sectional discovery (n = 2524) and validation (n = 518) design containing 3042 men free of cancer in EPIC, we estimated the associations of 24 dietary and lifestyle variables with each pattern and the contributing individual metabolites. Associations statistically significant after both correction for multiple testing (False Discovery Rate = 0.05) in the discovery set and at p < 0.05 in the validation set were considered robust. Intakes of alcohol, total fish products, and its subsets total fish and lean fish were positively associated with Pattern 1. Body mass index (BMI) was positively associated with Pattern 2, which appeared to be driven by a strong positive BMI-glutamate association. Finally, both BMI and fatty fish were inversely associated with Pattern 3. In conclusion, these results indicate associations of fish and its subtypes, alcohol, and BMI with metabolite patterns that are inversely associated with risk of aggressive prostate cancer.
KW  - cross-sectional (Other)
KW  - diet (Other)
KW  - metabolites (Other)
KW  - prostate cancer (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36014812
DO  - DOI:10.3390/nu14163306
UR  - https://inrepo02.dkfz.de/record/181492
ER  -