TY  - JOUR
AU  - Zhu, Anna
AU  - Kuznia, Sabine
AU  - Niedermaier, Tobias
AU  - Holleczek, Bernd
AU  - Schöttker, Ben
AU  - Brenner, Hermann
TI  - Consistent Inverse Associations of Total, 'Bioavailable', Free, and 'Non-Bioavailable' Vitamin D with Incidence of Diabetes among Older Adults with Lower Baseline HbA1c (≤6
JO  - Nutrients
VL  - 14
IS  - 16
SN  - 2072-6643
CY  - Basel
PB  - MDPI
M1  - DKFZ-2022-02028
SP  - 3282
PY  - 2022
N1  - #EA:C070#LA:C070#
AB  - Serum 25-hydroxyvitamin (25(OH)D) levels are inversely associated with risk of diabetes. The 'free hormone hypothesis' suggests potential effects to be mainly related to concentrations of 'bioavailable' and free rather than total 25(OH)D. We assessed associations of serum concentrations of vitamin D-binding protein (VDBP), as well as total 'bioavailable', complementary 'non-bioavailable', and free 25(OH)D, with the risk of developing diabetes among non-diabetic older adults in a large population-based cohort study in Germany.We included 4841 non-diabetic older adults aged 50-75 years at the baseline exam from the ESTHER cohort conducted in Saarland, Germany, in 2001-2002. Concentrations of 'bioavailable' and free 25(OH)D were derived from serum concentrations of VDBP, total 25(OH)D, and albumin. Incidence of diabetes was ascertained during up to 14 years of follow-up. Associations were quantified by multivariable Cox proportional hazards regression models with comprehensive confounder adjustment.During a median follow-up of 10.6 years, 837 non-diabetic participants developed diabetes. We observed similar inverse associations with developing diabetes for VDBP (hazard ratio (HR) for lowest versus highest quintile: 1.37, 95
KW  - bioavailable 25(OH)D (Other)
KW  - free 25(OH)D (Other)
KW  - type 2 diabetes (Other)
KW  - vitamin D (Other)
KW  - vitamin D-binding protein (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36014788
DO  - DOI:10.3390/nu14163282
UR  - https://inrepo02.dkfz.de/record/181493
ER  -